3-Amino-1.1-dimethyl-3-phenyl-1-propanol | 14593-13-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Amino-1.1-dimethyl-3-phenyl-1-propanol
• 英文别名: 4-amino-2-methyl-4-phenylbutan-2-ol；4-Amino-2-methyl-4-phenyl-2-butanol
• CAS: 14593-13-6
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: BAOXLAKANOUOSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  benzyl (3-hydroxy-3-methyl-1-phenylbutyl)carbamate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以100%的产率得到3-Amino-1.1-dimethyl-3-phenyl-1-propanol
  参考文献：
  名称：

  3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: Discovery and exploration of the carboxyamide side chain

  摘要：

  A series of 3-(2-aminocarbonyl-4-phenoxymethylphenyl) propanoic acid analogs were synthesized and evaluated for their EP3 antagonist activity in the presence of additive serum albumin. Several compounds were biologically evaluated for their in vivo efficacy with respect to the PGE(2)-induced uterine contraction in pregnant rats as well as their pharmacokinetics. The discovery process of these potent and selective EP3 antagonists and their structure activity relationship are also presented. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.11.023

文献信息

• SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE
  申请人：Zhou Dong

  公开号：US20170197912A1

  公开（公告）日：2017-07-13

  The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.

  本公开涉及一种制备具有适用于高效放射标记的[F-18]磺酰氟形式的反应性[F-18]氟化物的方法，该方法无需通过阿泽特罗普蒸发步骤，而是通过使用阴离子交换树脂和磺酰氯，并且在PET放射性药物制造中的应用。
• [EN] PHOSPHONATE-CONTAINING CROSSLINKERS<br/>[FR] AGENTS DE RÉTICULATION CONTENANT DES PHOSPHONATES
  申请人：UNIV UTRECHT HOLDING BV

  公开号：WO2020060412A1

  公开（公告）日：2020-03-26

  Disclosed are phosphonate-containing trifunctional crosslinkers and methods for synthesizing same. The invention further pertains to using the trifunctional crosslinkers in methods for crosslinking, purifying, and characterizing biomolecules such as peptides, proteins and polynucleotides.

  揭示了含膦酸盐的三官能交联剂以及其合成方法。该发明还涉及在交联、纯化和表征肽、蛋白质和多核苷酸等生物分子的方法中使用这种三官能交联剂。
• SOLIFENACIN COMPOSITIONS
  申请人：Kharwade Pramod

  公开号：US20100137358A1

  公开（公告）日：2010-06-03

  Compositions and/or formulations comprising solifenacin or a salt thereof and processes for preparing the same. Certain compositions and formulations contain a stable amorphous form of solifenacin succinate.

  本发明涉及含有索利那非或其盐的组合物和/或配方，以及制备它们的过程。某些组合物和配方包含稳定的索利那非琥珀酸盐非晶态形式。
• NORIBOGAINE COMPOSITIONS
  申请人：Moriarty Robert M.

  公开号：US20130131046A1

  公开（公告）日：2013-05-23

  Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt % of ibogaine relative to the total amount of noribogaine.

  本发明涉及一种诺利波甘组合物，其包含非常高水平的2(R)，4(S)，5(S)，6(S)和18(R)对映体，相对于诺利波甘的总量，伊博甘的含量不超过0.5重量%。
• [EN] NORIBOGAINE COMPOSITIONS<br/>[FR] COMPOSITIONS DE NORIBOGAÏNE
  申请人：DEMERX INC

  公开号：WO2012012764A1

  公开（公告）日：2012-01-26

  Disclosed are noribogaine compositions comprising a very high level of the 2(R), 4(S), 5(S), 6(S) and 18(R) enantiomer and not more than 0.5 wt% of ibogaine relative to the total amount of noribogaine.

  公开的是含有非常高水平的2（R），4（S），5（S），6（S）和18（R）对映体的诺利波甲酸组合物，相对于诺利波甲酸的总量不超过0.5重量％的伊波甲酸。