O4,O6-((R)-亚苄基)-D-葡萄糖 | 83212-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 中文名称: O4,O6-((R)-亚苄基)-D-葡萄糖
• 英文名称: (2R,3R)-2,3-Dihydroxy-3-((2R,4R,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-propionaldehyde
• 英文别名: (2R,3R)-2,3-dihydroxy-3-((2R,4R,5R)-5-hydroxy-2-phenyl-1,3-dioxan-4-yl)propanal；O⁴,O⁶-((R)-benzylidene)-D-glucose；O⁴,O⁶-((R)-Benzyliden)-D-glucose；(2R,3R)-2,3-dihydroxy-3-[(2R,4R,5R)-5-hydroxy-2-phenyl-1,3-dioxan-4-yl]propanal
• CAS: 83212-64-0
• 化学式: C₁₃H₁₆O₆
• 分子量: 268.266
• InChiKey: XTVRQMKOKFFGDZ-ZOLYEBIHSA-N

物化性质

• 沸点：
  521.6±50.0 °C(Predicted)
• 密度：
  1.379±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  O4,O6-((R)-亚苄基)-D-葡萄糖 在 sodium periodate 、 水 、 碳酸氢钠 作用下， 生成 (2R,4S,5R)-2-phenyl-5-hydroxy-1,3-dioxane-4-methanol
  参考文献：
  名称：

  The Enantiomorphic Erythritol 4-Phosphates

  摘要：

  DOI：

  10.1021/ja01596a046
• 作为产物：
  描述：

  葡萄糖 在 苯甲醛 、 zinc(II) chloride 作用下， 生成 O4,O6-((R)-亚苄基)-D-葡萄糖
  参考文献：
  名称：

  Zervas, Chemische Berichte, 1931, vol. 64, p. 2289,2294

  摘要：

  DOI：

文献信息

• ACYLSULFAMIDE COMPOUND AND PHARMACEUTICAL USE THEREFOR
  申请人：Japan Tobacco Inc.

  公开号：EP4082614A1

  公开（公告）日：2022-11-02

  An acylsulfamide compound, or a pharmaceutically acceptable salt thereof, having NLRP3 inflammasome inhibitory activity, a pharmaceutical composition comprising the same, and their medical use, etc., are provided. A compound of Formula [Ia]: or a pharmaceutically acceptable salt thereof, wherein a partial structure: is: Ring Cy is an optionally substituted heteroaryl or phenyl; RDy and REy are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C1-4 haloalkyl, optionally substituted C3-6 cycloalkyl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl, or alternatively, RDy and REy may combine together with the nitrogen atom to which they attach to form heterocycloalkyl, etc.

  提供了一种具有NLRP3炎症小体抑制活性的酰基磺酰胺化合物或其药学上可接受的盐，以及包含其的制药组合物和它们的医药用途等。其中化合物为式[Ia]或其药学上可接受的盐，其中部分结构为：环Cy为可选取代的杂环芳基或苯基；RDy和REy各自独立地为氢、可选取代的C1-6烷基、可选取代的C1-4卤代烷基、可选取代的C3-6环烷基、可选取代的杂环环烷基或可选取代的杂环芳基，或者RDy和REy可以与它们所附着的氮原子结合形成杂环环烷基等。
• 128. Preparation and properties of some poly-O-acetylglycosyl chlorides of the “unstable” series
  作者：W. Korytnyk、J. A. Mills

  DOI：10.1039/jr9590000636

  日期：——
• Bergmann et al., Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1934, vol. 224, p. 52,54
  作者：Bergmann et al.

  DOI：——

  日期：——
• Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars
  作者：Eli Breuer、David Melumad、Shalom Sarel、Eva Margalith、Ehud Katz

  DOI：10.1021/jm00355a007

  日期：1983.1

  A series of aldehydo sugars was subjected to condensation reactions with active methylene compounds. Acetylacetone was condensed with 2,4-O-benzylidene-3,5-O-dibenzoyl-D-ribose (1), 2,4:3,5-O-dibenzylidene-D-ribose (6), 2,3,4,5-tetraacetyl-D-ribose (7), and 2,3,4,5,6-pentaacetyl-D-glucose (9) to yield 3-ylidene-2,4-pentanedione derivatives 2, 11, 12, and 13, respectively. Sugar derivatives 1 and 6 were also condensed with benzoylacetone to give 14 and 18, with acetoacetanilide to give 16 and 19, with malononitrile to give 17 and 20, and with alpha-(gamma-butyrolactonylidene)triphenylphosphorane to give 21 and 22, respectively. Condensation of 1 with dibenzoylmethane gave 15. The double bond in compounds 2 and 11 was saturated by hydrogenation to give 23 and 24. All alpha, beta-unsaturated carbonyl compounds obtained exhibited antiviral activity and cytotoxicity. Compound 11 was found to have the most significant and selective antiviral activity against herpes simplex virus.
• Brigl; Gruener, Chemische Berichte, 1932, vol. 65, p. 1428,1432
  作者：Brigl、Gruener

  DOI：——

  日期：——