2,2-di(cyclopropylmethyl)hydrazine-1-carboxylic acid tert-butyl ester

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2-di(cyclopropylmethyl)hydrazine-1-carboxylic acid tert-butyl ester
• 英文别名: N',N'-Bis-cyclopropylmethyl-hydrazinecarboxylic acid tert-butyl ester；tert-Butyl 2,2-bis(cyclopropylmethyl)hydrazinecarboxylate；tert-butyl N-[bis(cyclopropylmethyl)amino]carbamate
• 化学式: C₁₃H₂₄N₂O₂
• 分子量: 240.346
• InChiKey: OMTLONBHLMYGDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 环丙甲醛 在 sodium cyanoborohydride 作用下， 生成 2,2-di(cyclopropylmethyl)hydrazine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity

  摘要：

  Depeptidization efforts of the P-3-P-2 region of P-3 capped alpha-ketoamide inhibitor of HCV NS3 serine protease I are reported. We clearly established that N-methylation of the P-2 nitrogen and modification of the P-2' carboxylic acid terminus were essential for activity in the replicon assay. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.013

文献信息

• Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
  作者：Stéphane L. Bogen、Sumei Ruan、Rong Liu、Sony Agrawal、John Pichardo、Andrew Prongay、Bahige Baroudy、Anil K. Saksena、Viyyoor Girijavallabhan、F. George Njoroge

  DOI：10.1016/j.bmcl.2005.12.013

  日期：2006.3

  Depeptidization efforts of the P-3-P-2 region of P-3 capped alpha-ketoamide inhibitor of HCV NS3 serine protease I are reported. We clearly established that N-methylation of the P-2 nitrogen and modification of the P-2' carboxylic acid terminus were essential for activity in the replicon assay. (C) 2005 Elsevier Ltd. All rights reserved.