4-Propan-2-yloxy-2,3-dihydro-1-benzofuran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 4-Propan-2-yloxy-2,3-dihydro-1-benzofuran
• 英文别名: 4-propan-2-yloxy-2,3-dihydro-1-benzofuran
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.23
• InChiKey: UJSRHKVLXNIIQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TRIAZOLES AS KV3 INHIBITORS
  申请人：AUTIFONY THERAPEUTICS LIMITED

  公开号：US20150111910A1

  公开（公告）日：2015-04-23

  Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.

  公式（I）的化合物可用于调节Kv3.1，Kv.3.2和Kv3.3通道，并在相关疾病的治疗或预防中具有用途。
• Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US10246454B2

  公开（公告）日：2019-04-02

  The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

  本发明涉及式 (I) 的新型取代吡啶-哌嗪酮衍生物 其中 R1、R2、R3、R4、R5、L、Z 和 X 具有权利要求中定义的含义。根据本发明的化合物可用作γ 分泌酶调节剂。本发明进一步涉及制备这种新型化合物的工艺、包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。
• HYDANTOIN DERIVATIVES AS KV3 INHIBITORS
  申请人：AUTIFONY THERAPEUTICS LIMITED

  公开号：US20150157631A1

  公开（公告）日：2015-06-11

  The present invention relates to the prophylaxis of acute noise-induced hearing loss by administering a compound of formula (I): wherein: W is group (Wa), group (Wb) or group (Wc):
• MODULATORS OF KV3 CHANNELS TO TREAT PAIN
  申请人：Autifony Therapeutics Limited

  公开号：US20220071998A1

  公开（公告）日：2022-03-10

  The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof:
• US9422252B2
  申请人：——

  公开号：US9422252B2

  公开（公告）日：2016-08-23