Carbamic acid, methyl(methylthio)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester | 50539-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: Carbamic acid, methyl(methylthio)-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
• 英文别名: (2,2-dimethyl-3H-1-benzofuran-7-yl) N-methyl-N-methylsulfanylcarbamate
• CAS: 50539-80-5
• 化学式: C₁₃H₁₇NO₃S
• 分子量: 267.35
• InChiKey: XGRHWGZYFDQGOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  64.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE)
  申请人：Carlier Paul

  公开号：US20120122970A1

  公开（公告）日：2012-05-17

  The present invention includes insecticidal carbamates that are useful, for example, for the control of insects, such as mosquitoes, which can be used in applications where exposure to and/or contact with humans is likely. The insecticides of the present invention include phenyl N-methyl carbamates and compositions comprising them that exhibit species-selective inhibition of acetylcholinesterase (AChE) and are preferably toxic to mosquitoes but not humans. Of particular interest are compounds of Formula (I) and Formula (II): Compounds of Formula (I) and Formula (II) are especially suitable for insecticide treated nets and indoor residual spraying for mosquito control.

  本发明涉及杀虫的氨基甲酸酯，例如用于控制蚊子等昆虫的氨基甲酸酯，可用于可能接触人类的应用中。本发明的杀虫剂包括苯基N-甲基氨基甲酸酯和包含它们的组合物，这些组合物表现出对乙酰胆碱酯酶（AChE）的物种选择性抑制，并且最好对蚊子有毒而不对人类有毒。特别感兴趣的是化合物I和化合物II的公式：化合物I和化合物II特别适合用于杀虫剂处理的蚊帐和室内残留喷雾，以控制蚊子。