2',3',5'-Tri-O-methylcytidine | 86881-29-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2',3',5'-Tri-O-methylcytidine
• 英文别名: 4-amino-1-[3,4-dimethoxy-5-(methoxymethyl)oxolan-2-yl]pyrimidin-2-one
• CAS: 86881-29-0
• 化学式: C₁₂H₁₉N₃O₅
• 分子量: 285.3
• InChiKey: UTRLDURUQJFKCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Nanoparticulate Compositions for Targeted Delivery of Acid Labile, Lipophilic Prodrugs of Cancer Chemotherapeutics and Their Preparation
  申请人：Arbor Therapeutics, LLC

  公开号：US20150079189A1

  公开（公告）日：2015-03-19

  In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection.