1,3-bis-(3-methyl-benzothiazol-2-yl)-trimethinium | 244049-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1,3-bis-(3-methyl-benzothiazol-2-yl)-trimethinium
• 英文别名: 3-methyl-2-[3-(3-methyl-3H-benzothiazol-2-ylidene)-propenyl]-benzothiazolium；(2E)-3-methyl-2-[(E)-3-(3-methyl-1,3-benzothiazol-3-ium-2-yl)prop-2-enylidene]-1,3-benzothiazole
• CAS: 244049-69-2
• 化学式: C₁₉H₁₇N₂S₂
• 分子量: 337.489
• InChiKey: WRYJHERQVXYYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  60.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-bis-(3-methyl-benzothiazol-2-yl)-trimethinium 在 N,N-二乙基苯胺 作用下， 生成 2-[3-(3-methyl-3H-benzothiazol-2-ylidene)-propenyl]-benzothiazole
  参考文献：
  名称：

  Kiprianow; Tolmatschew, Ukrainskij Khimicheskij Zhurnal, 1959, vol. 25, p. 337,340

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM
  申请人：Schmidt Boris

  公开号：US20130287700A1

  公开（公告）日：2013-10-31

  Subject of the present invention are compounds with high affinity for the Aβ protein, α-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.

  本发明的主题是具有高亲和力的化合物，用于Aβ蛋白、α-突触核蛋白或Tau-PHF聚集物，适用于作为体内诊断神经退行性疾病（如阿尔茨海默病和帕金森病）的首选荧光探针。这些化合物具有适当的物理化学性质（激发波长、发射波长、斯托克斯位移、消光），以及对目标蛋白的高亲和力和选择性。
• MACROPHAGE IDENTIFICATION AGENT, AND IDENTIFICATION METHOD, SORTING METHOD, EVALUATION METHOD, SCREENING METHOD AND KIT USING THE MACROPHAGE IDENTIFIER AGENT
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20160018389A1

  公开（公告）日：2016-01-21

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物对巨噬细胞亚型进行识别的方法。本发明的另一个目的是提供一种巨噬细胞识别试剂，其中当添加有机化合物时得到的光谱特征取决于巨噬细胞亚型而不同。本发明的另一个目的是提供一种利用巨噬细胞识别试剂进行巨噬细胞亚型评估的方法，一种用于巨噬细胞亚型与测试物之间相关性分析的方法，一种用于巨噬细胞亚型与测试物之间相关性筛选的方法，以及一种试剂盒。提供了一种利用添加有机化合物得到的光谱特征不同取决于巨噬细胞亚型的巨噬细胞亚型识别方法。
• Colored photosensitive resin composition, and color filter array and solid-state image pickup device using the same
  申请人：Miya Yoshiko

  公开号：US20080237553A1

  公开（公告）日：2008-10-02

  A colored photosensitive resin composition comprising an alkali-soluble resin, a photosensitive compound, a curing agent, a solvent and a colorant represented by the formula (I): The colored photosensitive resin composition can form a color filter array which shows good spectral characteristics.

  一种有色光敏树脂组合物，包括碱溶性树脂、光敏化合物、固化剂、溶剂和由式(I)表示的着色剂。该有色光敏树脂组合物可以形成一个显示良好光谱特性的彩色滤光片阵列。
• Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10041937B2

  公开（公告）日：2018-08-07

  An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

  本发明的一个目的是提供一种利用有机化合物识别巨噬细胞亚型的方法。本发明的另一个目的是提供一种含有有机化合物的巨噬细胞识别剂，其中添加有机化合物时获得的光谱特性因巨噬细胞亚型的不同而不同。本发明的另一个目的是提供一种使用巨噬细胞鉴定剂的巨噬细胞亚型的评估方法、巨噬细胞亚型与测试物质之间相关性的分析方法、巨噬细胞亚型与测试物质之间相关性的筛选方法和试剂盒。本发明提供了一种巨噬细胞亚型的鉴别方法，该方法利用了添加有机化合物后获得的光谱特性随巨噬细胞亚型的不同而不同的特点。
• Photosensitive composition, photosensitive lithography plate and method for producing lithography plate
  申请人：Matsumura Toshiyuki

  公开号：US20070020555A1

  公开（公告）日：2007-01-25

  Disclosed is a light sensitive composition containing a compound A having a group capable of undergoing radical polymerization, a compound B having a group capable of undergoing cationic polymerization, a photopolymerization initiator C, and a polymer binder D, the light sensitive composition being characterized in that the photopolymerization initiator C comprises an iron-arene complex and a halogenated alkyl group-containing compound.