3,7,8,9-Tetrahydro-8-hydroxy-1,3,7,9-tetramethyl-1H-purine-2,6-dione | 64265-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3,7,8,9-Tetrahydro-8-hydroxy-1,3,7,9-tetramethyl-1H-purine-2,6-dione
• 英文别名: 8-hydroxy-1,3,7,9-tetramethyl-8H-purine-2,6-dione
• CAS: 64265-14-1
• 化学式: C₉H₁₄N₄O₃
• 分子量: 226.23
• InChiKey: BMMHFCISVMJUSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Polynucleotide intercalator interceptors and inhibitors
  申请人：Lyles B. Mark

  公开号：US20050065335A1

  公开（公告）日：2005-03-24

  A method of using modified xanthine molecules as a binding agent is disclosed. Xanthine molecules with at least one substitution of a methyl group at the N1, N3, N7, or N9 position bind to intercalating molecules efficiently. This method can be applied to inhibiting intercalating molecules from binding to nucleic acids, as well as removing intercalating molecules that have been bound to nucleic acids. This method can also be applied to synthesize an efficient drug delivery system for compounds that have low solubility in aqueous media, including anti-neoplastic agents. The method can also be applied to flurosecently labeling nucleic acids.

  本研究公开了一种使用改性黄嘌呤分子作为结合剂的方法。在 N1、N3、N7 或 N9 位上至少有一个甲基被取代的黄嘌呤分子能有效地与插层分子结合。这种方法可用于抑制插层分子与核酸结合，以及去除已与核酸结合的插层分子。这种方法还可用于合成一种高效的药物输送系统，用于输送在水介质中溶解度低的化合物，包括抗肿瘤药物。该方法还可用于对核酸进行荧光标记。
• POLYNUCLEOTIDE INTERCALATOR INTERCEPTORS AND INHIBITORS
  申请人：Lyles, Mark B.

  公开号：EP1318796A2

  公开（公告）日：2003-06-18
• US7662767B2
  申请人：——

  公开号：US7662767B2

  公开（公告）日：2010-02-16
• [EN] POLYNUCLEOTIDE INTERCALATOR INTERCEPTORS AND INHIBITORS<br/>[FR] SUBSTANCES D'INTERCEPTION ET D'INHIBITION DE MOLECULES INTERCALANTES DE POLYNUCLEOTIDES
  申请人：LYLES MARK B

  公开号：WO2002045707A2

  公开（公告）日：2002-06-13

  A method of using modified xanthine molecules as a binding agent is disclosed. Xanthine molecules with at least one substitution of a methyl group at the N1, N3, N7, or N9 position bind to intercalating molecules efficiently. This method can be applied to inhibiting intercalating molecules from binding to nucleic acids, as well as removing intercalating molecules that have been bound to nucleic acids. This method can also be applied to synthesize an efficient drug delivery system for compounds that have low solubility in aqueous media, including anti-neoplastic agents. The method can also be applied to flurosecently labeling nucleic acids.