9-(Cyclopenten-1-yl)purin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(Cyclopenten-1-yl)purin-6-amine
• 化学式: C₁₀H₁₁N₅
• 分子量: 201.23
• InChiKey: LLGPVZKAHQNCMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT<br/>[FR] INHIBITEURS D'HISTONE MÉTHYLTRANSFÉRASE DOT1L NE CONTENANT PAS DE RIBOSE DESTINÉS AU TRAITEMENT DU CANCER
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2015013256A1

  公开（公告）日：2015-01-29

  A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl: R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if X = S, R2 = 0; Y is C3 or C4; Z1 is O, S, N, or CH2; and Z2 is N or CR4, wherein R4 is a halogen, alkyl, aryl or a 5- or 6-membered heterocycle; and wherein said compound is selective for DOT1L Methyl Transferase.

  一种符合以下公式I的化合物，其药学上可接受的盐，其前体药物，或其组合物：其中R1为H，甲基或苄基；R2为2-氰乙基，2-甲氧羰基乙基或2-碘乙基；X为N或S；其中如果X = S，则R2 = 0；Y为C3或C4；Z1为O，S，N或CH2；Z2为N或CR4，其中R4为卤素，烷基，芳基或5-或6-成员杂环；所述化合物对DOT1L甲基转移酶具有选择性。
• Novel neplanocin derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0347852A2

  公开（公告）日：1989-12-27

  This invention relates to certain neplanocin derivatives which are useful in inhibiting AdoMet-dependent trans­methylation and in the treatment of patients afflicted with neoplastic or viral disease states.

  本发明涉及某些肾素衍生物，这些衍生物可用于抑制 AdoMet 依赖性转甲基化和治疗肿瘤性或病毒性疾病患者。
• NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT
  申请人：BAYLOR COLLEGE OF MEDICINE

  公开号：US20160168185A1

  公开（公告）日：2016-06-16

  A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R 1 is H, methyl, or benzyl; R 2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if X=S, R 2 =O; Y is C 3 or C 4 ; Z 1 is O, S, N, or CH 2 ; and Z 2 is N or CR 4 , wherein R 4 is a halogen, alkyl, aryl or a 5- or 6-membered heterocycle; and wherein said compound is selective for DOT1L Methyl Transferase.