[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(propanoyl)amino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(propanoyl)amino]propanoate
• 化学式: C₃₅H₄₈ClN₃O₁₀
• 分子量: 706.2
• InChiKey: BVXGVRDMHBYRCQ-HCWYFPGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  49
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Methods of use of anti-CD123 antibodies and antigen-binding fragments thereof
  申请人：IMMUNOGEN, INC.

  公开号：US10442865B2

  公开（公告）日：2019-10-15

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the a chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.

  本发明一般涉及与 CD123 抗原（白细胞介素 3 受体或 IL-3Rα 的 a 链）结合的抗体、其抗原结合片段、多肽和免疫结合剂。本发明还涉及使用此类 CD123 结合分子诊断和治疗疾病（如 B 细胞恶性肿瘤）的方法。
• Anti-CD123 antibodies and conjugates and derivatives thereof
  申请人：IMMUNOGEN, INC.

  公开号：US10919969B2

  公开（公告）日：2021-02-16

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.

  本发明一般涉及与 CD123 抗原（白细胞介素 3 受体或 IL-3Rα 的 α 链）结合的抗体、其抗原结合片段、多肽和免疫结合剂。本发明还涉及使用此类 CD123 结合分子诊断和治疗疾病（如 B 细胞恶性肿瘤）的方法。
• ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF
  申请人：IMMUNOGEN, INC.

  公开号：US20180079819A1

  公开（公告）日：2018-03-22

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.
• EPCAM ANTIBODIES, ACTIVATABLE ANTIBODIES, AND IMMUNOCONJUGATES, AND USES THEREOF
  申请人：ImmunoGen, Inc.

  公开号：US20210403594A1

  公开（公告）日：2021-12-30

  The disclosure generally relates to antibodies and antibody fragments that specifically bind human EpCAM, EpCAM activatable antibodies, and immunoconjugates thereof, as well as, methods of making and using the antibodies, antibody fragments, activatable antibodies, and immunoconjugates, for the diagnosis and treatment of diseases such as cancer.
• US9415118B2
  申请人：——

  公开号：US9415118B2

  公开（公告）日：2016-08-16