tripchlorolide | 132368-08-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: tripchlorolide
• 英文别名: (1S,2S,4R,5R,6R,7R,8S,10S,12S)-5-chloro-6,7-dihydroxy-1-methyl-6-propan-2-yl-3,9,15-trioxahexacyclo[10.7.0.02,4.02,8.08,10.013,17]nonadec-13(17)-en-16-one
• CAS: 132368-08-2
• 化学式: C₂₀H₂₅ClO₆
• 分子量: 396.868
• InChiKey: OIMACDABKWJVSQ-LZVGCMTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  triptolide 在 吡啶盐酸盐 作用下， 以 丙酮 为溶剂， 反应 6.0h， 以75%的产率得到tripchlorolide
  参考文献：
  名称：

  CN114716503

  摘要：

  公开号：

文献信息

• [EN] GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF<br/>[FR] CONJUGUÉS GLUCOSE DE TRIPTOLIDE, ANALOGUES ET UTILISATIONS CORRESPONDANTS
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2017136739A1

  公开（公告）日：2017-08-10

  Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti -proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

  提供了由三尖杉酯与葡萄糖结合形成的葡萄糖-三尖杉酯共轭物，这些化合物具有有效的抗增殖活性，并且相比自然存在的三尖杉酯化合物具有更好的耐受性。
• An Improved Semi-synthesis of Tripchlorolide
  作者：Weihong Liang、Yunshan Wu、Bo Liu

  DOI：10.1080/00304948.2023.2207440

  日期：2024.1.2
• TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
  申请人：Hong Kong Baptist University

  公开号：US20160362691A1

  公开（公告）日：2016-12-15

  Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R 1 -R 7 , G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.
• US9809822B2
  申请人：——

  公开号：US9809822B2

  公开（公告）日：2017-11-07