[1,1'-二(环己烷)]-1,1'-二胺 | 1636-35-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: [1,1'-二(环己烷)]-1,1'-二胺
• 英文名称: 1.1'-diamino-bicyclohexyl
• 英文别名: bicyclohexyl-1,1'-diyldiamine；Bicyclohexyl-1,1'-diyldiamin；1,1'-Diamino-dicyclohexyl；Diaminobicyclohexyl；1-(1-aminocyclohexyl)cyclohexan-1-amine
• CAS: 1636-35-7
• 化学式: C₁₂H₂₄N₂
• 分子量: 196.336
• InChiKey: SAZUUDGWWJRKBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [1,1'-二(环己烷)]-1,1'-二胺 、 nickel(II) monochloroacetate 以 not given 为溶剂， 生成 {Ni(1.1'-C12H24N2)}(CH2ClCO2)2*4H2O
  参考文献：
  名称：

  Kircheiss, A., Zeitschrift fur Naturforschung, 1965, vol. 20b, p. 706 - 707

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1'-dinitro-bicyclohexyl 在 盐酸 、 tin 、 乙醇 作用下， 生成 环己亚基环己烷 、 [1,1'-二(环己烷)]-1,1'-二胺
  参考文献：
  名称：

  Dornow; Fust, Chemische Berichte, 1957, vol. 90, p. 1769,1773

  摘要：

  DOI：

文献信息

• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• Colorless Transparent Polyimide Composite Film and Method for Producing Same
  申请人：Makinoshima Takashi

  公开号：US20080020217A1

  公开（公告）日：2008-01-24

  The present invention provides a colorless, transparent polyimide composite film containing a polyimide (A) having a specific repeating unit, and an organic-treated layered silicate (B) obtained through treatment with an organic onium ion having a specific structure such that the organic-treated layered silicate (B) is dispersed in the polyimide (A); and as well a method for producing a colorless, transparent polyimide composite film, the method including forming a film-form mixture through extrusion or application, onto a support, of a three-component liquid mixture containing the polyimide (A), the organic-treated layered silicate (B), and an organic solvent (C) having a specific SP value; and subsequently removing the organic solvent (C) from the film-form mixture. The polyimide composite film of the present invention is a colorless, transparent film containing the polyimide (A) and the organic-treated layered silicate (B) which is very uniformly dispersed in the polyimide, exhibiting excellent heat resistance and mechanical properties, and exhibiting flexibility.

  本发明提供了一种无色透明的聚酰亚胺复合膜，其中包含具有特定重复单元的聚酰亚胺（A）和经有机阳离子处理的具有特定结构的有机处理层状硅酸盐（B），使得经有机处理的层状硅酸盐（B）分散在聚酰亚胺（A）中；以及一种生产无色透明聚酰亚胺复合膜的方法，该方法包括通过挤出或应用形成膜形混合物，将聚酰亚胺（A）、经有机处理的层状硅酸盐（B）和具有特定SP值的有机溶剂（C）的三组分液体混合物涂覆到支撑物上，并随后从膜形混合物中去除有机溶剂（C）。本发明的聚酰亚胺复合膜是一种无色透明的膜，其中包含聚酰亚胺（A）和经有机处理的层状硅酸盐（B），后者在聚酰亚胺中非常均匀地分散，具有优异的耐热性和机械性能，同时还具有柔韧性。
• Antimicrobial Compounds and Formulations
  申请人：Svendsen John Sigurd

  公开号：US20120108520A1

  公开（公告）日：2012-05-03

  The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

  本发明涉及使用一种分子，其包含长度为2至35个非氢原子的骨架，并且至少连接有两个笨重和亲脂性基团，并且具有至少一个阳离子大于阴离子的基团，在制造破坏微生物细胞膜的药物方面使用该分子。另外，本发明还涉及使用一种分子作为膜作用抗微生物剂，该分子包括长度为2至35个非氢原子的骨架，并且共价连接有一个超大的、亲脂性的基团，包括至少9个非氢原子，并且具有至少两个阳离子大于阴离子的基团。本发明还涉及涉及这样的分子的治疗方法，特别是包括肽衍生物和肽类似物的肽。
• THERMOSETTING POLYIMIDE RESIN COMPOSITION AND CURED PRODUCT THEREOF
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2009058A1

  公开（公告）日：2008-12-31

  The present invention can provide a thermosetting polyimide resin composition that provides a cured product having flexibility and adhesiveness, has a long pot life, and has high heat resistance. The thermosetting polyimide resin composition of the present invention is obtained by the following steps (1) to (3): Step (1): mixing a tetracarboxylic acid component containing at least one compound selected from a tetracarboxylic dianhydride represented by formula (1), a tetracarboxylic acid represented by formula (2) and a derivative of the tetracarboxylic acid, with an aliphatic diamine represented by formula (3), to make a number of moles of the tetracarboxylic acid component excessive to a number of moles of the aliphatic diamine, and reacting them under heating to synthesize a polyimide (A); Step (2): mixing the polyimide (A) obtained in the step (1) with an aromatic diamine represented by formula (4), and reacting them under heating to synthesize a polyimide (B); and Step (3): mixing the polyimide (B) obtained in the step (2) with a bismaleimide compound represented by formula (5): (wherein R1 represents a tetravalent organic group) (wherein R1 represents a tetravalent organic group, and Y1 to Y4 each independently represent a hydrocarbon group having from 1 to 8 carbon atoms)         H2N-X1-NH2     (3) (wherein X1 represents a divalent organic group having from 1 to 221 carbon atoms, and containing an aliphatic group or an alicyclic group bonded directly to an amino group, wherein the divalent organic group may contain a substituent, such as an aromatic group, an ether group and the like, as a part of the structure thereof)         H2N-X2-NH2     (4) (wherein X2 represents a divalent organic group having from 6 to 27 carbon atoms, and containing an aromatic ring bonded directly to an amino group, wherein the divalent organic group may contain a substituent, such as an aliphatic group, an alicyclic group and the like, as a part of the structure thereof) (wherein Z represents a divalent organic group).

  本发明可提供一种热固性聚酰亚胺树脂组合物，该组合物可提供具有柔韧性和粘合性的 固化产品，具有较长的固化寿命和较高的耐热性。 本发明的热固性聚酰亚胺树脂组合物通过以下步骤（1）至（3）获得： 步骤 (1)：将含有至少一种选自式（1）代表的四羧酸二酐、式（2）代表的四羧酸和四羧酸衍生物的化合物的四羧酸组分与式（3）代表的脂肪族二胺混合，使四羧酸组分的摩尔数超过脂肪族二胺的摩尔数，并在加热下反应合成聚酰亚胺（A）； 步骤(2)：将步骤(1)中得到的聚酰亚胺(A)与由式(4)代表的芳香族二胺混合，并在加热下反应，合成聚酰亚胺(B)；以及 步骤(3)：将步骤(2)中得到的聚酰亚胺(B)与式(5)代表的双马来酰亚胺化合物混合： (其中 R1 代表四价有机基团） (其中 R1 代表四价有机基团，Y1 至 Y4 各自独立地代表具有 1 至 8 个碳原子的烃基团）。 H2N-X1-NH2 (3) (其中 X1 代表具有 1 至 221 个碳原子的二价有机基团，并含有直接与氨基键合的脂 族基团或脂环族基团，二价有机基团可含有取代基，如芳香基团、醚基团等，作为其 结构的一部分） H2N-X2-NH2 (4) (其中 X2 代表具有 6 至 27 个碳原子的二价有机基团，该二价有机基团含有一个直接与氨基键合的芳香环，其中二价有机基团可含有一个取代基，如脂肪族基团、脂环族基团等，作为其结构的一部分）。 (其中 Z 代表二价有机基团）。
• Antitumoural therapies
  申请人：Lytix Biopharma AS

  公开号：EP2338522A1

  公开（公告）日：2011-06-29

  The invention relates to a peptide consisting of 2-4 amino acids comprising at least three lipophilic groups of at least 5 non-hydrogen atoms wherein one of the molecule's lipophilic groups incorporates 6 or more non-hydrogen atoms and a second lipophilic group incorporates 10 or more non-hydrogen atoms and wherein at least one lipophilic group incorporates a closed ring of at least 6 non-hydrogen atoms, said peptide having at least one more cationic than anionic moiety, and wherein at least one of the amino acids has a cationic side chain (R group) and at least one of the lipophilic groups is an amino acid side chain (R group), for use as an antitumoural agent and to a peptide consisting of 2-4 amino acids comprising a lipophilic group comprising at least 13 non-hydrogen atoms and one or more closed rings of 4 or more non-hydrogen atoms, wherein at least one of the amino acids has a cationic side chain (R group) and at least one of the amino acid side chains (R groups) is a lipophilic group of at least 4 non-hydrogen atoms, said peptide having at least two more cationic than anionic moieties, also for use as an antitumoural agent.

  本发明涉及一种由 2-4 个氨基酸组成的多肽，这些氨基酸至少包含三个亲脂基团，其中一个分子的亲脂基团包含 6 个或更多的非氢原子，第二个亲脂基团包含 10 个或更多的非氢原子，并且至少有一个亲脂基团包含至少 6 个非氢原子的闭环、所述肽具有至少一个阳离子多于阴离子的分子，其中至少一个氨基酸具有阳离子侧链（R 基团），至少一个亲脂基团是氨基酸侧链（R 基团）、用于抗肿瘤剂的肽，由 2-4 个氨基酸组成，其中亲脂基团包括至少 13 个非氢原子和一个或多个由 4 个或更多非氢原子组成的闭环、其中至少有一个氨基酸具有阳离子侧链（R 基团），至少有一个氨基酸侧链（R 基团）是由至少 4 个非氢原子组成的亲脂基团，所述肽具有至少两个阳离子多于阴离子的分子，也可用作抗肿瘤剂。