1-Cyano-1-isopropenylcyclohexan | 63089-66-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Cyano-1-isopropenylcyclohexan
• 英文别名: 1-Prop-1-en-2-ylcyclohexane-1-carbonitrile
• CAS: 63089-66-7
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: JRBPOVDDTJHDFC-UHFFFAOYSA-N

物化性质

• 沸点：
  239.0±19.0 °C(Predicted)
• 密度：
  0.90±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,5-二溴戊烷 、 3-甲基巴豆腈 生成 1-Cyano-1-isopropenylcyclohexan
  参考文献：
  名称：

  Synthesis of olefins via reduction-decyanation of .beta.,.gamma.-unsaturated nitriles

  摘要：

  DOI：

  10.1021/jo00440a029

文献信息

• Cycloalkyl inhibitors of potassium channel function
  申请人：——

  公开号：US20040072880A1

  公开（公告）日：2004-04-15

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  新型环烷基化合物可用作钾通道功能抑制剂（特别是Kv1亚家族电压门控K+通道的抑制剂，特别是抑制与超快速激活延迟整流K+电流IKur相关的Kv1.5），使用这些化合物预防和治疗心律失常和IKur相关疾病的方法，以及含有这些化合物的制药组合物。
• CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION
  申请人：Lloyd John

  公开号：US20070142333A1

  公开（公告）日：2007-06-21

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  新型环烷基化合物可作为钾通道功能抑制剂使用（特别是钾离子电压门控K+通道的Kv1亚家族的抑制剂，特别是与超快速激活延迟整流K+电流IKur相关的Kv1.5抑制剂），使用这种化合物预防和治疗心律失常和IKur相关疾病的方法，以及含有这种化合物的药物组合物。
• MARSHALL J. A.; BIERENBAUM R., J. ORG. CHEM., 1977, 42, NO 20, 3309-3311
  作者：MARSHALL J. A.、 BIERENBAUM R.

  DOI：——

  日期：——
• US7202253B2
  申请人：——

  公开号：US7202253B2

  公开（公告）日：2007-04-10
• [EN] CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION<br/>[FR] INHIBITEURS CYCLOALKYLE DE LA FONCTION DU CANAL DE POTASSIUM
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003063797A2

  公开（公告）日：2003-08-07

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.