2-amino-hexanenitrile | 27243-20-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-hexanenitrile
• 英文别名: (+/-)-α-Amino-capronsaeurenitril；2-Aminohexanenitrile
• CAS: 27243-20-5
• 化学式: C₆H₁₂N₂
• 分子量: 112.175
• InChiKey: FHKPTEOFUHYQFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-amino-hexanenitrile 在 水 作用下， 以8%的产率得到L-正亮氨酸
  参考文献：
  名称：

  Nitrilases

  摘要：

  公开号：

  EP2319919B1
• 作为产物：
  描述：

  正戊醛 、 氰化钠 在 氯化铵 作用下， 以 乙醚 为溶剂， 生成 2-amino-hexanenitrile
  参考文献：
  名称：

  Überchelatbildendeα-氨基碳原子-硫代酰胺

  摘要：

  α-氨基硫代酰胺-潜在的金属螯合剂-是通过与H 2 S反应从α-氨基腈或其衍生物合成的。

  DOI：

  10.1002/hlca.19620450414

文献信息

• Novel compounds and compositions as protease inhibitors
  申请人：——

  公开号：US20020052378A1

  公开（公告）日：2002-05-02

  The present invention relates to novel cysteine protease inhibitors of Formula I: 1 the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.

  本发明涉及一种新型半胱氨酸蛋白酶抑制剂的化学式I： 1 其药用盐及N-氧化物衍生物，它们作为治疗剂的用途以及制备它们的方法。
• Nitrilase from rhodococcus rhodochrous ncimb 11216
  申请人：——

  公开号：US20030157672A1

  公开（公告）日：2003-08-21

  The invention relates to nucleic acid sequences which code for a polypeptide having nitrilase activity, to nucleic acid constructs comprising the nucleic acid sequences, and to vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention further relates to amino acid sequences which are encoded by the nucleic acid sequences, and to microorganisms comprising the nucleic acid sequences, the nucleic acid constructs or vectors comprising the nucleic acid sequences or the nucleic acid constructs. The invention additionally relates to an enzymatic process for preparing carboxylic acids from the corresponding nitrites.

  这项发明涉及编码具有腈酶活性的多肽的核酸序列，包括包含该核酸序列的核酸构建物，以及包含该核酸序列或核酸构建物的载体。该发明还涉及由该核酸序列编码的氨基酸序列，以及包含该核酸序列、核酸构建物或包含该核酸序列或核酸构建物的载体的微生物。此外，该发明还涉及一种从相应的亚硝酸盐制备羧酸的酶法过程。
• Method of producing dinitrile compounds
  申请人：Rosier Cecile

  公开号：US20060258873A1

  公开（公告）日：2006-11-16

  The present invention relates to a process for the manufacture of compounds comprising two nitrile functional groups. It relates more particularly to a process for the manufacture of dinitrile compounds from compounds comprising a nitrile functional group and an ethylenic unsaturation in the presence of a catalytic system comprising an organometallic complex and a cocatalyst of the Lewis acid type. The process of the invention comprises a stage of treatment of the reaction medium resulting from the hydrocyanation which makes it possible to extract and recover the metal element of the Lewis acid.

  本发明涉及一种制备含有两个腈官能团的化合物的方法。更具体地，涉及一种在存在包括一个有机金属配合物和一种Lewis酸类辅助催化剂的催化系统的情况下，从含有腈官能团和乙烯不饱和度的化合物制备二腈化合物的方法。本发明的方法包括处理由氢氰化反应产生的反应介质的阶段，该阶段使得能够提取和回收Lewis酸的金属元素。
• HYDROGENATION CATALYSTS, THE PRODUCTION AND THE USE THEREOF
  申请人：Wigbers Christof Wilhelm

  公开号：US20110313186A1

  公开（公告）日：2011-12-22

  The present invention relates to catalysts and processes for preparation thereof, said catalysts being obtainable by contacting a monolithic catalyst support with a suspension which comprises one or more insoluble or sparingly soluble compounds of the elements selected from the group of the elements cobalt, nickel and copper. The invention further relates to the use of the inventive catalyst in a process for hydrogenating organic substances, especially for hydrogenating nitriles, and to a process for hydrogenating organic compounds, which comprises using an inventive catalyst in the process.

  本发明涉及催化剂和其制备方法，所述催化剂可通过将单体催化剂载体与包含来自元素钴、镍和铜组的元素中的一种或多种不溶或难溶化合物的悬浮液接触而获得。本发明还涉及在氢化有机物质的过程中使用这种创新催化剂，特别是用于氢化腈的过程，并涉及一种氢化有机化合物的过程，其中在过程中使用了一种创新催化剂。
• METHOD FOR IMPROVING THE CATALYTIC ACTIVITY OF MONOLITHIC CATALYSTS
  申请人：Wigbers Christof Wilhelm

  公开号：US20110313187A1

  公开（公告）日：2011-12-22

  The present invention relates to a process for improving the catalytic properties of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The invention further relates to a process for hydrogenating compounds which comprise at least one unsaturated carbon-carbon, carbon-nitrogen or carbon-oxygen bond in the presence of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The present invention also relates to the use of a basic compound selected from the group of the alkali metals, alkaline earth metals and rare earth metals for improving the catalytic properties of a catalyst comprising cobalt and/or copper and/or nickel, said catalyst being present in the form of a structured monolith.

  本发明涉及一种改善催化剂性能的过程，所述催化剂包括从钴、镍和铜组成的元素中选择的一个或多个元素，所述催化剂呈现为结构化单体，并通过将催化剂与从碱金属、碱土金属和稀土金属组中选择的一个或多个碱性化合物接触来实现。本发明还涉及一种在存在从钴、镍和铜组成的元素中选择的一个或多个元素的催化剂的情况下，通过将催化剂与从碱金属、碱土金属和稀土金属组中选择的一个或多个碱性化合物接触来氢化包含至少一个不饱和碳-碳、碳-氮或碳-氧键的化合物的过程。本发明还涉及使用从碱金属、碱土金属和稀土金属组中选择的碱性化合物来改善包括钴和/或铜和/或镍的催化剂的催化性能的用途，所述催化剂呈现为结构化单体。