tert-Butylaminofumaronitril | 71200-73-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tert-Butylaminofumaronitril
• 英文别名: (Z)-2-(tert-butylamino)but-2-enedinitrile
• CAS: 71200-73-2
• 化学式: C₈H₁₁N₃
• 分子量: 149.195
• InChiKey: ZWWDNZDSMVFJKU-DAXSKMNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  chloromaleo(fumaro)nitrile 、 叔丁胺 以 乙醇 为溶剂， 生成 tert-Butylaminofumaronitril 、 t-butylaminomaleonitrile
  参考文献：
  名称：

  Kopranenkov,V.N. et al., Journal of Organic Chemistry USSR (English Translation), 1979, vol. 15, p. 962 - 967

  摘要：

  DOI：

文献信息

• Kopranenkov,V.N. et al., Journal of Organic Chemistry USSR (English Translation), 1979, vol. 15, p. 962 - 967
  作者：Kopranenkov,V.N. et al.

  DOI：——

  日期：——
• Synthesis and photodynamic activity of some tetraazoporphyrin derivatives
  作者：AR Morgan、NH Petousis、JE van Lier

  DOI：10.1016/s0223-5234(97)84358-9

  日期：1997.1

  Photodynamic therapy (PDT) is a treatment modality for a number of human neoplasms. The drug preparation most widely used in current clinical trials is photofrin. Photofrin lacks definite structure and as a result the interpretation of its pharmacokinetic data is difficult. Thus the development of new sensitizers of known structure such as the phthalocyanines and naphthalocyanines has been proposed. In our approach, we have studied the use of tetraazaporphyrins (porphyrazines) as sensitizers. This class of sensitizers has received very little attention. A number of porphyrazines were synthesized via the cyclization of tricyanovinyl amines and dinitrile amines in pentanol solution of magnesium oxide. These porphyrazines were converted to their respective zinc chelates and tested for their stability in acidic media and for their ability to photoinactivate cells in culture. Results indicate that these porphyrazines show promise and must be investigated further for applications in PDT.