copper(1+);iodozinc(1+);propanenitrile;cyanide | 121340-52-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: copper(1+);iodozinc(1+);propanenitrile;cyanide
• CAS: 121340-52-1
• 化学式: CN*C₃H₄N*Cu*I*Zn
• 分子量: 335.93
• InChiKey: KZOAEKRZVSLUHZ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.17
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tricarbonyl(tropone)iron 、 copper(1+);iodozinc(1+);propanenitrile;cyanide 在 三氟化硼乙醚 作用下， 以 四氢呋喃 为溶剂， 以97%的产率得到
  参考文献：
  名称：

  高度功能化的锌铜试剂RCu（CN）ZnI与三氟化硼硼酸盐促进的三氢番茄红素（三氢呋喃酮）的迈克尔加成反应

  摘要：

  The zinc-copper reagents RCu(CN)ZnI, containing various functional groups such as a cyanide, ester, thio ester or benzyl, react with (tropone)iron tricarbonyl in the presence of an excess of boron trifluoride etherate to afford the Michael adducts in excellent yields. Cyano-substituted 1,4-adducts undergo an intramolecular cyclization reaction in situ, leading to highly functionalized bicyclo[5.3.0]decane and -[5.4.0]undecane derivatives, whereas treatments of an ester-substituted 1,4-adduct with lithium diisopropylamide (LDA) under an atmosphere of carbon monoxide furnishes a highly functionalized bridged bicyclo [4.2.1]nonenecarboxylic acid derivative in 88 % yield.

  DOI：

  10.1021/om00017a041

文献信息

• Michael Addition Reactions of the Highly Functionalized Zinc-Copper Reagents RCu(CN)ZnI to (Tropone)iron Tricarbonyl Promoted by Boron Trifluoride Etherate
  作者：Ming-Chang P. Yeh、Chong-Chen Hwu、Chuen-Her Ueng、Huei-Lin Lue

  DOI：10.1021/om00017a041

  日期：1994.5

  The zinc-copper reagents RCu(CN)ZnI, containing various functional groups such as a cyanide, ester, thio ester or benzyl, react with (tropone)iron tricarbonyl in the presence of an excess of boron trifluoride etherate to afford the Michael adducts in excellent yields. Cyano-substituted 1,4-adducts undergo an intramolecular cyclization reaction in situ, leading to highly functionalized bicyclo[5.3.0]decane and -[5.4.0]undecane derivatives, whereas treatments of an ester-substituted 1,4-adduct with lithium diisopropylamide (LDA) under an atmosphere of carbon monoxide furnishes a highly functionalized bridged bicyclo [4.2.1]nonenecarboxylic acid derivative in 88 % yield.