1-Methoxy-N,2-dimethylpropan-2-amine | 1177316-77-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Methoxy-N,2-dimethylpropan-2-amine
• CAS: 1177316-77-6
• 化学式: C₆H₁₅NO
• mdl: MFCD11053914
• 分子量: 117.19
• InChiKey: PEZCONMNKQLFHS-UHFFFAOYSA-N

物化性质

• 沸点：
  116.1±13.0 °C(Predicted)
• 密度：
  0.820±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid 、 1-Methoxy-N,2-dimethylpropan-2-amine 以isolated (30 mg, 42.1%) as colorless sticky liquid的产率得到5-cyclopropyl-6-cyclopropylmethoxy-pyrazine-2-carboxylic acid (2-methoxy-1,1-dimethylethyl)methyl amide
  参考文献：
  名称：

  NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS

  摘要：

  本发明涉及一种化合物，其化学式为（I），其中R1至R4的定义如描述和权利要求书中所述。该化合物是CB2受体激动剂，可用于治疗多种疾病，如疼痛，动脉粥样硬化和青光眼。

  公开号：

  US20150299220A1

文献信息

• 1,3-DIHYDROISOBENZOFURAN DERIVATIVES
  申请人：OKUDA Ayumu

  公开号：US20090247587A1

  公开（公告）日：2009-10-01

  The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.

  该目的是提供一种新型的LXRβ激动剂，可用作预防和/或治疗动脉粥样硬化；动脉硬化，如糖尿病引起的动脉硬化；血脂异常；高胆固醇血症；与脂质相关的疾病；由炎性细胞因子引起的炎症性疾病；皮肤疾病，如过敏性皮肤病；糖尿病；或阿尔茨海默病的治疗剂。解决方法是由以下一般式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐，或它们的溶剂化合物。
• [EN] NOVEL PYRAZINE DERIVATIVES AS CB2 RECEPTOR AGONISTS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZINE COMME AGONISTES DES RÉCEPTEURS CB2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014086807A1

  公开（公告）日：2014-06-12

  The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 receptor agonist for use in the treatment of several disorders, such as pain, atherosclerosis and glaucoma.

  这项发明涉及一种化合物，其化学式为（I），其中R1至R4的定义如描述和索赔中所述。化合物的化学式（I）是一种CB2受体激动剂，用于治疗多种疾病，如疼痛、动脉粥样硬化和青光眼。
• SEPARATION OF HYDROGEN SULFIDE FROM NATURAL GAS
  申请人：Kortunov Pavel

  公开号：US20150027056A1

  公开（公告）日：2015-01-29

  A process for increasing the selectivity of an alkanolamine absorption process for selectively removing hydrogen sulfide (H 2 S) from a gas mixture which also contains carbon dioxide (CO 2 ) and possibly other acidic gases such as COS, HCN, CS 2 and sulfur derivatives of C 1 to C 4 hydrocarbons, comprises contacting the gas mixture with a liquid absorbent which is a severely sterically hindered capped alkanolamine. The improvement in selectivity is achieved at the high(er) pressures, typically least about 10 bara at conditions nearing the H 2 S/CO 2 equilibrium at which CO 2 begins to displace absorbed hydrosulfide species from the absorbent solution.

  一种增加烷基醇胺吸收过程的选择性的方法，以有选择地从气体混合物中去除硫化氢（H2S），该混合物还包含二氧化碳（CO2）和可能包含其他酸性气体，如COS、HCN、CS2和C1至C4烃的硫衍生物，包括将气体混合物与一种液体吸收剂接触，该吸收剂是一种严重的立体位阻末端烷基醇胺。在高压下（通常至少约10 bara）的改进选择性是在接近H2S / CO2平衡的条件下实现的，此时CO2开始从吸收剂溶液中置换吸收的硫化氢物种。
• PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20150299165A1

  公开（公告）日：2015-10-22

  The invention relates to CB2 agonists of formula (I) wherein R 1 to R 4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

  本发明涉及公式（I）中R1到R4如说明书和权利要求书中所定义的CB2激动剂。公式（I）的化合物可用作药物。
• PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF
  申请人：YU Henry

  公开号：US20160152626A1

  公开（公告）日：2016-06-02

  The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).

  本发明涉及吡唑化合物及其药学上可接受的组合物，作为卵泡刺激素受体（FSHR）的正向变构调节剂。