2-chlorocyclohexanecarboxaldehyde

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 2-chlorocyclohexanecarboxaldehyde
• 英文别名: 2-chlorocyclohexylketone；Cyclohexane,trans-1-chloro-2-nitroso-；2-chlorocyclohexane-1-carbaldehyde
• 化学式: C₇H₁₁ClO
• 分子量: 146.617
• InChiKey: KMRPGHDRZKCBOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-chlorocyclohexanecarboxaldehyde 在 盐酸 、 乙酸酐 、 sodium hydride 、 三乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 20.59h， 生成 sodium 4-(2-((E)-2-((E)-2-(4-(dihexyamino) phenoxy)-3-((E)-2-(1,1-dimethyl-3-(4-sulfonatebutyl)-1H-benzo[e]indol-2 (3H)-ylidene)ethylidene)cyclohexenyl)vinyl)-1,1-dimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate
  参考文献：
  名称：

  Fluorescent Probe for Imaging Lymph Nodes

  摘要：

  本发明公开了一种近红外荧光成像剂，包括吲哚菁绿类荧光染料和脂质体。本发明的近红外荧光成像剂在哨兵淋巴结中表现出高荧光强度和长时间的锚定，因此适用于在哨兵淋巴结导航手术中检测哨兵淋巴结。本发明还公开了一种吲哚菁绿衍生物，特别适用于本发明的近红外荧光成像剂中使用。

  公开号：

  US20160222211A1

文献信息

• Inhibitors of histone deacetylase
  申请人：——

  公开号：US20020115826A1

  公开（公告）日：2002-08-22

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及组蛋白去乙酰化酶的抑制。本发明提供了用于抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和状况的组合物和方法。
• AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE
  申请人：Kobayashi Yumi

  公开号：US20110201687A1

  公开（公告）日：2011-08-18

  An amide derivative represented by the following Formula (1) is provided as an amide derivative showing a significantly excellent effect for a pest control action. In the following Formula (1), A represents a carbon atom, a nitrogen atom, or the like, and K represents a non-metal atomic group necessary for forming a cyclic linking group derived from benzene or a heterocyclie. X represents a halogen atom or the like; n represents an integer of from 0 to 4 . R 1 and R 2 represent hydrogen atoms, alkyl groups, or the like. T represents —C(=G 1 )-Q 1 or —C(=G 1 )-G 2 Q 2 , and G 1 to G 3 each represent oxygen atoms or the like. Q 1 and Q 2 each represent a hydrogen atom, an alkyl group, an aryl group, or the like. Y 1 and Y 5 each represent a halogen atom or the like, Y 2 and Y 4 each represent a hydrogen atom or the like, and Y 3 represents a C2-C5 haloalkyl group.

  提供以下式子（1）表示的酰胺衍生物，作为一种表现出显著杀虫作用的酰胺衍生物。在下面的式子（1）中，A代表碳原子、氮原子或类似物，K代表必要的非金属原子团，用于形成从苯或杂环中得到的环链连接基。X代表卤素原子或类似物；n代表0至4的整数。R1和R2代表氢原子、烷基或类似物。T代表- C（= G1）- Q1或- C（= G1）- G2Q2，G1到G3每个代表氧原子或类似物。Q1和Q2每个代表氢原子、烷基、芳基或类似物。Y1和Y5每个代表卤素原子或类似物，Y2和Y4每个代表氢原子或类似物，Y3代表C2-C5卤代烷基。
• Inhibitors of Histone Deacetylase
  申请人：Delorme Daniel

  公开号：US20090181971A1

  公开（公告）日：2009-07-16

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的技术。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了治疗细胞增殖性疾病和病状的组合物和方法。
• Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs thereof and their preparation and uses for inhibiting blood platelet aggregation
  申请人：Sankyo Company Limited

  公开号：EP0542411A2

  公开（公告）日：1993-05-19

  Compounds of formula (I): in which: R¹ is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulphonyl, haloalkanesulphonyl or sulphamoyl; R² is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R³ is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is -NH- or oxygen or sulphur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.

  式(I)化合物： 其中R¹ 是氢、烷基、卤素、卤代烷基、羟基、烷氧基、卤代烷氧基、烷硫基、卤代烷硫基、氨基、烷酰基、卤代烷酰基、羧基、烷氧羰基、氨基甲酰基、氰基、硝基、烷磺酰基、卤代烷磺酰基或磺酰基；R² 是任选取代的烷酰基、任选取代的烯酰基、任选取代的环烷基羰基、取代的苯甲酰基或 5,6-二氢-1,4,2-二恶嗪-3-基；R³ 是氢、羟基、任选取代的烷氧基、烷氧基、烷甲氧基、烯甲氧基、环烷基羰基氧基、芳基羰基氧基、烷氧基羰基氧基、烷氧基羰基氧基、酞酰氧基、(5-甲基-2-氧代-1,3-二氧戊烯-4-基)甲氧基、(5-苯基-2-氧代-1,3-二氧戊烯-4-基)甲氧基、任选取代的氨基或硝基；Y 是-NH-或氧或硫；n 是 1 至 5；所述式（I）化合物的同系物和盐具有抑制血小板聚集的能力，因此可用于血栓和栓塞的治疗和预防。
• CYCLIC AMINO COMPOUNDS
  申请人：Sankyo Company Limited

  公开号：EP1063230A1

  公开（公告）日：2000-12-27

  Cyclic amino compounds represented by general formula (I) or pharmacologically acceptable salts thereof having an excellent antiplatelet aggregation effect; etc. and thus being useful as preventives or remedies for embolism, thrombosis or arterial sclerosis wherein R1 represents optionally substituted phenyl; R2 represents optionally substituted aliphatic acyl, optionally substituted benzoyl or alkoxycarbonyl; and R3 represents substituted and optionally ring-fused saturated cyclic amino.

  通式(I)代表的环状氨基化合物或其药理上可接受的盐，具有优异的抗血小板聚集作用等，因此可作为栓塞、血栓形成或动脉硬化的预防剂或治疗剂 其中R1代表任选取代的苯基；R2代表任选取代的脂肪族酰基、任选取代的苯甲酰基或烷氧基羰基；R3代表取代的和任选环融的饱和环状氨基。