1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid | 808137-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
• 英文别名: 1-isoquinolin-1-ylpyrrolo[2,3-b]pyridine-3-carboxylic acid
• CAS: 808137-96-4
• 化学式: C₁₇H₁₁N₃O₂
• 分子量: 289.293
• InChiKey: ZYUXGZVHGDRMNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 3-chlorocarbonyl-1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine
  参考文献：
  名称：

  [EN] 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
  [FR] DERIVES HETEROCYCLIQUES 3-(GUANIDINOCARBONYLE), LEUR PROCEDE DE PREPARATION ET INTERMEDIAIRES POUR LEDIT PROCEDE, LEUR UTILISATION EN TANT QUE MEDICAMENTS ET COMPOSITIONS PHARMACEUTIQUE LES COMPRENANT

  摘要：

  本发明涉及公式（I）的新化合物及其药学上可接受的盐。这些新化合物适用于例如心律失常药物，其具有心脏保护成分，用于预防和治疗心肌梗死以及治疗心绞痛。它们还能预防性地抑制与缺血性损伤发展相关的病理生理过程，特别是在诱发缺血性心律失常和心力衰竭方面。

  公开号：

  WO2004111048A1
• 作为产物：
  描述：

  3-trifluoroacetyl-1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine 在 sodium hydride 、 溶剂黄146 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 13.0h， 生成 1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
  参考文献：
  名称：

  [EN] 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
  [FR] DERIVES HETEROCYCLIQUES 3-(GUANIDINOCARBONYLE), LEUR PROCEDE DE PREPARATION ET INTERMEDIAIRES POUR LEDIT PROCEDE, LEUR UTILISATION EN TANT QUE MEDICAMENTS ET COMPOSITIONS PHARMACEUTIQUE LES COMPRENANT

  摘要：

  本发明涉及公式（I）的新化合物及其药学上可接受的盐。这些新化合物适用于例如心律失常药物，其具有心脏保护成分，用于预防和治疗心肌梗死以及治疗心绞痛。它们还能预防性地抑制与缺血性损伤发展相关的病理生理过程，特别是在诱发缺血性心律失常和心力衰竭方面。

  公开号：

  WO2004111048A1

文献信息

• Derivatives of 3-(guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
  申请人：Carry Jean-Christophe

  公开号：US20050014758A1

  公开（公告）日：2005-01-20

  The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

  本发明揭示和声明了I式化合物及其药物可接受的盐，以及使用该I式化合物，单独或与其他药物联合使用，作为具有心脏保护成分的抗心律失常药物，用于预防或治疗梗死，治疗心绞痛，并作为与缺血诱导损伤发展相关的病理生理过程的抑制剂，特别是在诱发缺血诱导的心脏心律失常和心力衰竭方面。本发明还揭示和声明了包括I式化合物或I式化合物与一种或多种其他药物组合的制药组合物，以及制备I式化合物的方法。
• Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：US07230007B2

  公开（公告）日：2007-06-12

  The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.

  本发明揭示和声明了式I的化合物及其药学上可接受的盐，并且揭示了使用该式I的化合物，无论是单独使用还是与其他药物联合使用，作为具有心脏保护成分的抗心律失常药物，用于预防或治疗梗死，治疗心绞痛，并作为抑制与缺血引起的损伤发展相关的病理生理过程的药物，特别是在触发缺血诱发的心脏心律失常和心力衰竭方面。还揭示和声明了包含式I化合物或式I化合物与一个或多个其他药物组合的制药组合物，以及制备式I化合物的方法。
• 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1641791A1

  公开（公告）日：2006-04-05
• US7230007B2
  申请人：——

  公开号：US7230007B2

  公开（公告）日：2007-06-12
• [EN] 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM<br/>[FR] DERIVES HETEROCYCLIQUES 3-(GUANIDINOCARBONYLE), LEUR PROCEDE DE PREPARATION ET INTERMEDIAIRES POUR LEDIT PROCEDE, LEUR UTILISATION EN TANT QUE MEDICAMENTS ET COMPOSITIONS PHARMACEUTIQUE LES COMPRENANT
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2004111048A1

  公开（公告）日：2004-12-23

  The present invention relates to the novel compounds of the formula (I) and their pharmaceutically acceptable salts. The inventive compounds are suitable, for example, as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiologicaI processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.

  本发明涉及公式（I）的新化合物及其药学上可接受的盐。这些新化合物适用于例如心律失常药物，其具有心脏保护成分，用于预防和治疗心肌梗死以及治疗心绞痛。它们还能预防性地抑制与缺血性损伤发展相关的病理生理过程，特别是在诱发缺血性心律失常和心力衰竭方面。