3'-azido-2',3'-dideoxy-E-5-styryluridine

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3'-azido-2',3'-dideoxy-E-5-styryluridine
• 英文别名: 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-[(E)-styryl]pyrimidine-2,4-dione；1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-[(E)-2-phenylethenyl]pyrimidine-2,4-dione
• 化学式: C₁₇H₁₇N₅O₄
• 分子量: 355.353
• InChiKey: JXIDKEQASZZESZ-XIKIYNFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3'-azido-2',3'-dideoxy-E-5-styryluridine 在 磷酸三乙酯 、 三氯氧磷 作用下， 反应 15.0h， 以47%的产率得到3'-azido-2',3'-dideoxy-E-5-styryluridine 5'-monophosphate
  参考文献：
  名称：

  Synthetic Nucleosides and Nucleotides. XXXI.¹Inhibitory Effects of 2′-Deoxy-5-styryluridine 5′-Triphosphate Analogues on Retroviral Reverse Transcriptases and Higher Eukaryotic DNA Polymerases

  摘要：

  Some new 5'-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3'-dideoxyUTP analogues.

  DOI：

  10.1080/15257779408012149

文献信息

• Synthetic Nucleosides and Nucleotides. XXXI.¹Inhibitory Effects of 2′-Deoxy-5-styryluridine 5′-Triphosphate Analogues on Retroviral Reverse Transcriptases and Higher Eukaryotic DNA Polymerases
  作者：Toyofumi Yamaguchi、Shunji Izuta、Motoshi Suzuki、Shonen Yoshida、Akio Matsukage、Mineo Saneyoshi

  DOI：10.1080/15257779408012149

  日期：1994.7

  Some new 5'-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3'-dideoxyUTP analogues.