Manzamine F

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: Manzamine F
• 英文别名: (1R,2R,12R,13S,16Z)-13-hydroxy-25-(8-hydroxy-9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-16,25-dien-7-one
• 化学式: C₃₆H₄₄N₄O₃
• 分子量: 580.8
• InChiKey: KYLZDBBEWRTKTG-UNFYSDSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  43
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  92.7
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Use of manzamine compounds in anti-cancer therapeutic regimens
  申请人：Guzman A. Esther

  公开号：US20070203113A1

  公开（公告）日：2007-08-30

  Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
• Use of Manzamine Compounds in Anti-Cancer Therapeutic Regimens
  申请人：Guzman Esther A.

  公开号：US20120289533A1

  公开（公告）日：2012-11-15

  Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
• US8232266B2
  申请人：——

  公开号：US8232266B2

  公开（公告）日：2012-07-31