1-(6-amino-2,2-dimethyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone | 144293-83-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1-(6-amino-2,2-dimethyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone
• 英文别名: 4-acetyl-6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazine；1-(6-Amino-2,2-dimethyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethan-1-one；1-(6-amino-2,2-dimethyl-3H-1,4-benzoxazin-4-yl)ethanone
• CAS: 144293-83-4
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: AHPJXNCRWIKYBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(6-amino-2,2-dimethyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone 在 三乙胺 、 三氟乙酸酐 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 4-acetyl-3,4-dihydro-2,2-dimethyl-6-trifluoroacetylamino-2H-1,4-benzoxazine
  参考文献：
  名称：

  Oxazinobenzazole compounds

  摘要：

  氧杂苯并唑衍生物的化学式(I)如下：其中R^1、R^2、R^3和R^4可以相同也可以不同，分别代表氢原子或较低的烷基基团；R^5和R^6与两个相邻的碳原子共同形成一个取代或未取代的含有至少两个氮原子并且可能含有一个或多个来自氧原子、硫原子和氮原子的杂原子的5-或6-成员杂环，m为0或1的整数，以及其药学上可接受的盐。本发明的化合物可用作抗痉挛药物。

  公开号：

  US05278158A1
• 作为产物：
  描述：

  2H-1,4-苯并噁嗪,4-乙酰基-3,4-二氢-2,2-二甲基-6-硝基- 在 镍 作用下， 以 乙醇 为溶剂， 以giving 18.2 g of crude 4-acetyl-6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazine的产率得到1-(6-amino-2,2-dimethyl-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone
  参考文献：
  名称：

  Oxazinobenzazole compounds

  摘要：

  氧杂苯并咪唑衍生物，化学式为(I)：##STR1## 其中R.sup.1、R.sup.2、R.sup.3和R.sup.4可以相同也可以不同，分别代表氢原子或低碳基；R.sup.5和R.sup.6与相邻的两个碳原子结合形成一个取代或未取代的5-或6-成员杂环，其中至少有两个氮原子，可选地有一个或多个异原子，所选异原子包括氧原子、硫原子和氮原子；m为0或1的整数，以及其药学上可接受的盐。本发明的化合物可用作抗痉挛药物。

  公开号：

  US05278158A1

文献信息

• Substituted alkylamine derivatives and methods of use
  申请人：Amgen Inc.

  公开号：US20030225106A1

  公开（公告）日：2003-12-04

  Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的胺对预防治疗疾病有效，如血管生成介导的疾病。本发明包括新的化合物、类似物、前药和药用可接受的盐，药物组合物和预防治疗疾病和其他疾病或状况的方法，包括癌症等。本发明还涉及制造这类化合物的过程以及在此类过程中有用的中间体。
• Substituted amine derivatives and methods of use
  申请人：Amgen Inc.

  公开号：US20030203922A1

  公开（公告）日：2003-10-30

  Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的胺类化合物对于预防和治疗疾病，如血管生成介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受盐，用于预防和治疗涉及癌症等疾病和其他疾患或病况的药物组合物和方法。该发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
• Substituted arylamine derivatives and methods of use
  申请人：——

  公开号：US20020147198A1

  公开（公告）日：2002-10-10

  Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  所选化合物对预防和治疗疾病，如介导血管生成的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受的衍生物，用于预防和治疗涉及癌症等疾病和其他疾病或情况的药物组合物和方法。该发明还涉及用于制备这种化合物的工艺，以及在这些工艺中有用的中间体。
• Substituted anthranilic amide derivatives and methods of use
  申请人：Amgen Inc.

  公开号：US20040087568A1

  公开（公告）日：2004-05-06

  Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的化合物对于预防和治疗疾病，如介导血管生成的疾病具有有效性。该发明涵盖了新的化合物、类似物、前药和其药学上可接受的盐、药物组合物以及预防和治疗癌症等涉及疾病和其他疾病或状况的方法。该发明还涉及制备这些化合物的过程，以及在这些过程中有用的中间体。
• Substituted aryl-amine derivatives and methods of use
  申请人：Yuan Chenguang Chester

  公开号：US20060040966A1

  公开（公告）日：2006-02-23

  Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R 1 and R 2 for each formula are defined herein. The invention further includes analogs, prodrugs and pharmaceutically acceptable salts and derivatives of Formulas I and II, as well as pharmaceutical compositions, medicaments and methods thereof for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的胺类化合物对于预防和治疗由血管生成介导的疾病等疾病有效。该发明涵盖了式I和式II的新型化合物，其中每个式中的R、R1和R2如本文所定义。该发明还包括式I和式II的类似物、前药和药物可接受的盐和衍生物，以及用于预防和治疗涉及癌症等疾病和其他疾病或病症的药物组合物、药物和方法。该发明还涉及制备这种化合物的工艺以及在这种工艺中有用的中间体。