2-benzooxazol-2-yl-acetamide | 34564-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-benzooxazol-2-yl-acetamide
• 英文别名: Benzoxazolylacetamide；2-(1,3-benzoxazol-2-yl)acetamide
• CAS: 34564-12-0
• 化学式: C₉H₈N₂O₂
• 分子量: 176.175
• InChiKey: KYRRAGIOAZNKGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  69.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-苯并噁唑-2-乙腈 在 氟硼酸铵 、 [RhCl2(p-cymene)]2 、 水 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以75%的产率得到2-benzooxazol-2-yl-acetamide
  参考文献：
  名称：

  Bidentate Oxazoline−Imine Ruthenium(II) Complexes: Intermediates in the Methanolysis/Hydration of Nitrile Groups

  摘要：

  The reaction of [RuCl2(p-cymene)](2) with benzoxazoleacetonitriles and NH4+BF4- in methanol leads to bidentate N,N'-benzoxazole-methoxyimine-ruthenium(II) complexes 7, corresponding to the addition of methanol to the ruthenium(II)-activated nitrile triple bond. The X-ray structure of a complex 7 shows equivalent Ru-N and slightly different C=N bond distances. The catalytic hydration of benzoxazolacetonitriles with [RuCl2(p-cymene)](2) in methanol/water leads to quantitative formation of corresponding amides under mild conditions.

  DOI：

  10.1021/om100674x

文献信息

• DYEING COMPOSITION, DYED PRODUCT, AND AZO COLORING AGENT
  申请人：FUJIFILM Corporation

  公开号：US20200354576A1

  公开（公告）日：2020-11-12

  Provided are a dyeing composition which contains an azo coloring agent represented by Formula 1 or 2, a dyed product which is obtained by being dyed with the dyeing composition, and a novel azo coloring agent. In Formulae 1 and 2, C 1 represents a heteroaromatic group, A 1 and B 1 each independently represent a heteroaromatic group, an aromatic group, or a group having a methine structure, and at least one of A 1 or B 1 represents a heteroaromatic group, D 1 represents an anthraquinonyl group, and E 1 represents a heteroaromatic group, an aromatic group, or a group having a methine structure. A 1 -N═N—C 1 —N═N—B 1 Formula 1 D 1 -N═N-E 1 Formula 2

  提供了一种染料组合物，其中包含由式1或2表示的偶氮着色剂，用该染料组合物染色后获得的染色产品，以及一种新型偶氮着色剂。在式1和2中，C1代表杂芳族基，A1和B1各自独立地表示杂芳族基、芳香族基或具有亚甲基结构的基团，且A1或B1中至少一个代表杂芳族基，D1代表蒽醌基，E1代表杂芳族基、芳香族基或具有亚甲基结构的基团。A1-N═N—C1—N═N—B1（式1），D1-N═N-E1（式2）。
• Hair dye composition
  申请人：Kao Corporation

  公开号：EP1366752A1

  公开（公告）日：2003-12-03

  The present invention is directed to a hair dyeing composition comprising an azo dye of the following general formula (I)A - N = N - B    where A = monovalent, optionally substituted heterocyclic group binding via the carbon atom to the azo group, that does not contain carboxy (-CO2H) or sulfo groups (SO3H) or quaternary ammonium groups and B = heterocyclic, aromatic or alkyl group containing a dissociative proton and, which is free of carboxy (-CO2H) or sulfo groups (-SO3H) or quaternary ammonium groups. Additionally, the present invention describes a method of dyeing human or animal hair by using such a dye and the use of this direct azo dye for dyeing human or animal hair. The use of this direct azo dye can impart the hair with an extremely vivid colour and has a less colour fade over the time.

  本发明涉及一种染发组合物，包括以下通用式(I)A - N = N - B的偶氮染料，其中A = 通过碳原子与偶氮基结合的一价的、可选地取代的杂环基团，不含羧基（-CO2H）或磺酸基（SO3H）或季铵基团；B = 含有可解离质子的杂环、芳香或烷基团，且不含羧基（-CO2H）或磺酸基（-SO3H）或季铵基团。此外，本发明描述了一种通过使用这种染料来染色人类或动物头发的方法，以及使用这种直接偶氮染料来染色人类或动物头发。使用这种直接偶氮染料可以使头发呈现极为鲜艳的颜色，并且随着时间的推移，颜色褪色较少。
• Benzoxazole inhibitors of 15-lipoxygenase
  申请人：Weinstein S. David

  公开号：US20070049628A1

  公开（公告）日：2007-03-01

  The present application provides benzoxazole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

  本申请提供了15-LO的苯并咪唑抑制剂、含有此类抑制剂的制药组合物以及使用此类化合物和组合物治疗与15-LO级联相关的疾病的方法。
• [EN] VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS<br/>[FR] LIGANDS DE RECEPTEUR VANILLOIDE ET LEUR UTILISATION DANS DES TRAITEMENTS
  申请人：AMGEN INC

  公开号：WO2004014871A1

  公开（公告）日：2004-02-19

  Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  含有通用结构和组成的化合物及其组合物，用于治疗急性、炎症性和神经痛、牙痛、普通头痛、偏头痛、集群性头痛、混合性血管和非血管综合症、紧张性头痛、普通炎症、关节炎、风湿性疾病、骨关节炎、炎症性肠病、炎症性眼病、炎症性或不稳定的膀胱疾病、牛皮癣、带有炎症成分的皮肤病、慢性炎症状况、炎症性疼痛及相关的高敏性和触痛，神经痛及相关的高敏性和触痛、糖尿病神经病疼痛、烧伤后神经痛、交感神经维持的疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸道、泌尿生殖系统、胃肠道或血管区域的内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、普通胃肠疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。
• [EN] PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN<br/>[FR] DERIVES DE PYRIMIDINE UTILISES COMME LIGANDS DE RECEPTEUR DE VANILLOIDE ET LEUR UTILISATION DANS LE TRAITEMENT DE LA DOULEUR
  申请人：AMGEN INC

  公开号：WO2005077944A1

  公开（公告）日：2005-08-25

  Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

  含有嘧啶醚化合物的组合物，用作vanilloid受体配体，用于治疗急性、炎症性和神经病理性疼痛、牙痛、普通头痛、偏头痛、群集性头痛、混合血管和非血管综合症、紧张性头痛、一般炎症、关节炎、风湿病、骨关节炎、炎症性肠病、炎症性眼病、炎症性或不稳定膀胱疾病、牛皮癣、具有炎症成分的皮肤疾病、慢性炎症状态、炎症性疼痛及相关的高敏性和触痛、神经病理性疼痛及相关的高敏性和触痛、糖尿病性神经病疼痛、交感神经维持的疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、胃肠或血管区域内脏运动障碍、创伤、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动性或过敏性鼻炎、支气管疾病或膀胱疾病。其中R1-R4和X的定义如权利要求中所述。