(1,2,3,4-tetrahydro-6-methoxy-2-oxonaphthalen-1-yl)acetonitrile | 306299-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1,2,3,4-tetrahydro-6-methoxy-2-oxonaphthalen-1-yl)acetonitrile
• 英文别名: 2-(6-methoxy-2-oxo-3,4-dihydro-1H-naphthalen-1-yl)acetonitrile
• CAS: 306299-87-6
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: KPFCHQLMMYGBPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1,2,3,4-tetrahydro-6-methoxy-2-oxonaphthalen-1-yl)acetonitrile 在 ammonium acetate 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 cis-3a,4,5,9b-tetrahydro-7-methoxy-1H-benzindol-2-ylamine
  参考文献：
  名称：

  N -(Sulfonamido)alkyl[tetrahydro-1 H -benzo[ e ]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor

  摘要：

  [3a,4,5,9b-Tetrahydro-1H-benzo[e]indol-2-yl]amines were prepared via reductive amination and concomitant cyclization of alpha-cyanomethyl-beta-aminotetralins. N-acylation with Omega-sulfonamido-carboxylic acids and subsequent reduction afforded a series of N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines, which bound to the human neuropeptide Y Y5 receptor with nanomolar affinity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00676-9
• 作为产物：
  描述：

  6-甲氧基-3,4-二氢-1H-2-萘酮 在 水 、 溶剂黄146 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 、 苯 为溶剂， 生成 (1,2,3,4-tetrahydro-6-methoxy-2-oxonaphthalen-1-yl)acetonitrile
  参考文献：
  名称：

  N -(Sulfonamido)alkyl[tetrahydro-1 H -benzo[ e ]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor

  摘要：

  [3a,4,5,9b-Tetrahydro-1H-benzo[e]indol-2-yl]amines were prepared via reductive amination and concomitant cyclization of alpha-cyanomethyl-beta-aminotetralins. N-acylation with Omega-sulfonamido-carboxylic acids and subsequent reduction afforded a series of N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines, which bound to the human neuropeptide Y Y5 receptor with nanomolar affinity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00676-9

文献信息

• 3a,4,5,9b-tetrahydro-1H-benz[e]indol-2-yl amine-derived neuropeptide Y receptors ligands useful in the treatment of obesity and other disorders
  申请人：Dax Scott

  公开号：US06841552B1

  公开（公告）日：2005-01-11

  Compounds of the formula: are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system.

  本公式化合物被披露为神经肽Y受体的配体，因此在肥胖和中枢神经系统疾病的治疗中是有用的。
• [EN] 3a,4,5,9b-TETRAHYDRO-1H-BENZ[e]INDOL-2-YL AMINE-DERIVED NEUROPEPTIDE Y RECEPTORS LIGANDS USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS<br/>[FR] LIGANDS DE RECEPTEURS DU NEUROPEPTIDE Y DERIVES DE 3a,4,5,9b-TETRAHYDRO-1H-BENZ[e]INDOL-2-YL AMINE, UTILISES POUR LE TRAITEMENT DE L'OBESITE ET D'AUTRES ETATS PATHOLOGIQUES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2000068197A1

  公开（公告）日：2000-11-16

  Compounds of formula: (A) are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system.

  公式为（A）的化合物被披露为神经肽Y受体的配体，因此在肥胖症和中枢神经系统疾病的治疗中是有用的。
• 3a,4,5,9b-tetrahydro-1H-benz[e]indol-2-yl amine-derived neuropeptideYreceptors ligands useful in the treatment of obesity and other disorders
  申请人：Dax Scott

  公开号：US20050054709A1

  公开（公告）日：2005-03-10

  Compounds of the formula: are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system.

  本发明公开了化学式的化合物，作为神经肽Y受体的配体，并且这些化合物在肥胖症和中枢神经系统疾病的治疗中有用。
• 3a,4,5,9b-TETRAHYDRO-1H-BENZ e]INDOL-2-YL AMINE-DERIVED NEUROPEPTIDE Y RECEPTORS LIGANDS USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1177172A1

  公开（公告）日：2002-02-06
• US6841552B1
  申请人：——

  公开号：US6841552B1

  公开（公告）日：2005-01-11