8-Methyl-2-methylamino-1,9-dihydro-purin-6-one | 113193-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-Methyl-2-methylamino-1,9-dihydro-purin-6-one
• 英文别名: 1,9-Dihydro-8-methyl-2-(methylamino)-6H-purin-6-one；8-methyl-2-(methylamino)-1,7-dihydropurin-6-one
• CAS: 113193-98-9
• 化学式: C₇H₉N₅O
• 分子量: 179.181
• InChiKey: KOMXJYASUSBYCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  7-Methoxy-2-methylamino-3H-pteridin-4-one 在 aluminum-mercury amalgam 、 氨 作用下， 以 甲醇 、 水 为溶剂， 反应 10.0h， 以38%的产率得到8-Methyl-2-methylamino-1,9-dihydro-purin-6-one
  参考文献：
  名称：

  Ring Transformation of Pterins to Guanines

  摘要：

  DOI：

  10.3987/r-1987-08-2091

文献信息

• [EN] 5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING<br/>[FR] 5-MÉTHOXY-NUCLÉOTIDES À TERMINAISON RAPIDEMENT PHOTOCLIVABLE NON BLOQUÉS EN 3'OH ET PROCÉDÉS DE SÉQUENÇAGE D'ACIDE NUCLÉIQUE
  申请人：LASERGEN INC

  公开号：WO2013040257A1

  公开（公告）日：2013-03-21

  The present invention relates generally to 3'-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.

  本发明通常涉及用于DNA和RNA测序和分析方法及系统中的3'-OH未阻断核苷酸和核苷的标记和未标记的5-甲氧基取代硝基苯基光致裂解终止基团。这些化合物可用作可逆终止剂，因为它们表现出快速的核苷酸结合动力学、单碱基终止、高核苷酸选择性和快速的终止基团裂解，导致自然发生的核苷酸。
• [EN] END CAPPED NUCLEIC ACID MOLECULES<br/>[FR] MOLÉCULES D'ACIDE NUCLÉIQUE À EXTRÉMITÉ COIFFÉE
  申请人：NOVARTIS AG

  公开号：WO2016098028A1

  公开（公告）日：2016-06-23

  The disclosure relates to nucleic acids that contain modifications at the 5'-end, 3'-end or 5'-end and 3'-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

  该披露涉及在5'-末端、3'-末端或5'-末端和3'-末端上含有修饰的核酸，以及可用于制备修饰核酸的化合物。与未经修饰的核酸相比，修饰核酸具有更好的表达、更低的免疫原性和更好的稳定性。
• [EN] LINKER COMPOUNDS<br/>[FR] COMPOSÉS DE LIAISON
  申请人：MPEG LA L L C

  公开号：WO2021226454A1

  公开（公告）日：2021-11-11

  Linker compounds, methods of making them, and methods of using them as linking agents for oligonucleotides and other chemical and biological substances are described. Embodiments of linker compounds are configured or selected to exhibit higher stability to cleavage by serum nucleases relative to intracellular nucleases, enabling enhanced control of longevity and hence bioavailability to a target cell of the chemical and biological substances linked together by such linker compounds when administered to a subject.

  本文描述了连接剂化合物、制备方法以及将它们用作寡核苷酸和其他化学和生物物质的连接剂的使用方法。连接剂化合物的实施例被配置或选择以相对于细胞内核酸酶具有更高的稳定性，从而使得通过这种连接剂化合物连接在一起并在给予受试者时可控制生物和化学物质的寿命和因此生物可用性增强到目标细胞。
• Metal complexes of N-heterocyclic carbenes as radiopharmaceuticals and antibiotics
  申请人：Youngs Wiley

  公开号：US20070021401A1

  公开（公告）日：2007-01-25

  A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or more tissues of a patient includes administering an effective amount of a complex of a N-heterocyclic amine and a radioactive metal. A method for treating urinary tract infections utilizing silver complexes of N-heterocyclic carbenes. N-heterocyclic carbenes of the present invention may be represented by the formula wherein Z is a heterocyclic group, and R 1 and R 2 are, independently or in combination, hydrogen or a C 1 -C 12 organic group selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heterocyclic, and alkoxy groups and substituted derivatives thereof.

  一种抑制微生物生长的方法包括给予有效量的N-杂环胺的银络合物。一种治疗癌细胞或成像患者一个或多个组织的方法包括给予有效量的N-杂环胺和放射性金属的络合物。一种利用N-杂环卡宾银络合物治疗尿路感染的方法。本发明的N-杂环卡宾可以用以下式表示，其中Z是杂环基，而R1和R2是独立或组合的氢或选择自烷基、环烷基、烯基、环烯基、炔基、芳基、芳基烷基、烷基芳基、杂环和烷氧基和其取代衍生物的C1-C12有机基。
• Metal Complexes of N-Heterocyclic Carbenes as Radiopharmaceuticals and Antibiotics
  申请人：Youngs Wiley J.

  公开号：US20080267867A1

  公开（公告）日：2008-10-30

  A method for inhibiting microbial growth comprises administering an effective amount of a silver complex of a N-heterocyclic amine. A method for treating cancer cells or a method for imaging one or more tissues of a patient includes administering an effective amount of a complex of a N-heterocyclic amine and a radioactive metal. N-heterocyclic carbenes of the present invention may be represented by formula (I) wherein Z is a heterocyclic group, and R 1 and R 2 are, independently or in combination, hydrogen or a C 1 -C 12 organic group selected from the group consisting of alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, arylalkyl, alkylaryl, heterocyclic, and alkoxy groups and substituted derivatives thereof.

  一种抑制微生物生长的方法包括给予一种N-杂环胺的银络合物有效量。一种治疗癌细胞或成像患者的一个或多个组织的方法包括给予一种N-杂环胺和放射性金属的络合物有效量。本发明的N-杂环卡宾可以用式(I)表示，其中Z是一个杂环基团，R1和R2独立或组合地是氢或C1-C12有机基团，所述有机基团选自烷基，环烷基，烯基，环烯基，炔基，芳基，芳基烷基，烷基芳基，杂环和其取代衍生物。