2-(5-methyl-thiophen-2-yl)-imidazo[1,2-a]pyridine | 475992-49-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(5-methyl-thiophen-2-yl)-imidazo[1,2-a]pyridine
• 英文别名: 2-(5-Methyl-2-thienyl)imidazo[1,2-a]pyridine；2-(5-methylthiophen-2-yl)imidazo[1,2-a]pyridine
• CAS: 475992-49-5
• 化学式: C₁₂H₁₀N₂S
• 分子量: 214.291
• InChiKey: AEWGBRQXKVKPIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Substituted imidazo[1,2-A] pyridine derivatives
  申请人：——

  公开号：US20020188128A1

  公开（公告）日：2002-12-12

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列新颖的化合物，化学式为I，并通过给予有效治疗剂量的化合物化学式1来治疗或预防mGluR5受体介导的疾病的方法，其中R1和R2从氢、(C1-6)-烷基、卤素、羟基、(C1-6)-烷氧基中选择，A在描述中有定义，或其药用盐。
• Substituted imidazo [1,2-a] pyridine derivatives
  申请人：——

  公开号：US20030212096A1

  公开（公告）日：2003-11-13

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列新型化合物I的方法，以及通过给予化合物公式1的治疗有效量或预防mGluR5受体介导的疾病的方法，其中R1和R2选择自氢，(C1-6)-烷基，卤素，羟基，(C1-6)-烷氧基和A在说明中定义，或其药学上可接受的盐。
• Substituted imidazo[1,2-a]pyridine derivatives
  申请人：——

  公开号：US20040180921A1

  公开（公告）日：2004-09-16

  The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount of a compound formula 1 wherein R 1 and R 2 are selected from hydrogen, (C 1-6 )-alkyl, halogen, hydroxy, (C 1-6 )-alkoxy and A is defined the description, or a pharmaceutically acceptable salt thereof.

  本发明涉及一系列公式I的新化合物以及通过给予公式1中化合物的治疗有效量来治疗或预防mGluR5受体介导的疾病的方法，其中R1和R2选择自氢、(C1-6)烷基、卤素、羟基、(C1-6)烷氧基，A的定义如说明书所述，或其药学上可接受的盐。
• ANTIGELLING AGENT FOR HYDROCARBON MIXTURE CONTAINING CONJUGATED DIENE AND METHOD OF PREVENTING CLOGGING OF APPARATUS FOR SEPARATING AND PURIFYING THE MIXTURE
  申请人：Nippon Zeon Co., Ltd.

  公开号：EP1184444A1

  公开（公告）日：2002-03-06

  An Anti-gelling agent for a hydrocarbon mixture containing a conjugated diene, which comprises (a) at least one compound selected from the group consisting of compounds having an NO radical in the molecule, and precursor compounds capable of forming an NO radical, (b) a phosphorus-containing compound, and (c) at least one compound selected from the group consisting of heterocyclic aldehydes, aromatic aldehydes and condensates of these aldehydes. Clogging in an apparatus for separating and refining a hydrocarbon mixture containing a conjugated diene can be prevented by adding the anti-gelling agent in the apparatus.

  一种用于含有共轭二烯的烃混合物的抗胶凝剂，它包括：(a) 至少一种从分子中含有 NO 自由基的化合物和能形成 NO 自由基的前体化合物组成的组中选出的化合物；(b) 一种含磷化合物；(c) 至少一种从杂环醛、芳香醛和这些醛的缩合物组成的组中选出的化合物。在分离和提炼含有共轭二烯的烃混合物的设备中加入抗胶凝剂，可防止堵塞。
• METHOD OF SEPARATING/PURIFYING CONJUGATED DIENE AND SEPARATION/PURIFICATION APPARATUS
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP1437336A1

  公开（公告）日：2004-07-14

  A method of separating and purifying conjugated dienes includes a step of obtaining a first bottom product by taking out a hydrocarbon mixture including conjugated diene under an environment in the presence of a polymerization inhibitor including at least one of nitrite and di-lower aklylhydroxylamine in a first extractive distillation column; a step of obtaining a second bottom product and a distillation portion by distilling the first bottom product in a first diffusion column; a step of obtaining a third bottom product by taking out the distillation portion under an environment in the presence of the polymerization inhibitor in a second extractive distillation column; a step of obtaining a fourth bottom product by distilling the third bottom product in a second diffusion column; a step of recovering the second bottom product and fourth bottom product and supplying to the first extractive distillation column and/or second extractive distillation column; a step of measuring concentration of a polymerization inhibitor included in the second bottom product and/or fourth bottom product; and a control step of controlling the concentration of the polymerization inhibitor included in the second bottom product and/or fourth bottom product by changing a supply amount of the polymerization inhibitor to the first extractive distillation column and/or second extractive distillation column in accordance with the measured concentration of the polymerization inhibitor. According to the method, generation of rubbery substances in an apparatus can be efficiently and stably suppressed and an excessive polymerization inhibitor is not left in conjugated dienes.

  一种分离和纯化共轭二烯的方法包括以下步骤：在存在聚合抑制剂（包括亚硝酸盐和二-低烷基羟胺中的至少一种）的环境下，在第一萃取蒸馏塔中取出包括共轭二烯在内的烃混合物，从而获得第一底部产物；在第一扩散塔中蒸馏第一底部产物，从而获得第二底部产物和蒸馏部分；在存在聚合抑制剂（包括亚硝酸盐和二-低烷基羟胺中的至少一种）的环境下，在第一萃取蒸馏塔中取出第三底部产物；通过在第一扩散塔中蒸馏第一底部产物，获得第二底部产物和蒸馏部分的步骤；通过在第二萃取蒸馏塔中在存在聚合抑制剂的环境下取出蒸馏部分，获得第三底部产物的步骤；通过在第二扩散塔中蒸馏第三底部产物，获得第四底部产物的步骤；回收第二底层产品和第四底层产品并将其供给第一萃取蒸馏塔和/或第二萃取蒸馏塔的步骤；测量第二底层产品和/或第四底层产品中聚合抑制剂浓度的步骤；以及根据聚合抑制剂的测量浓度改变第一萃取蒸馏塔和/或第二萃取蒸馏塔中聚合抑制剂的供给量，从而控制第二底层产品和/或第四底层产品中聚合抑制剂浓度的控制步骤。根据该方法，可有效、稳定地抑制设备中橡胶物质的生成，并且不会在共轭二烯中残留过量的聚合抑制剂。