N-(2,3-dihydro-1H-isoindol-5-yl)acetamide hydrochloride | 412294-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(2,3-dihydro-1H-isoindol-5-yl)acetamide hydrochloride
• 英文别名: N-(2,3-dihydro-1H-isoindol-5-yl)acetamide;hydrochloride
• CAS: 412294-03-2
• 化学式: C10H13ClN2O
• 分子量: 212.67
• InChiKey: BSOMJIZKGJDLEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.67
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.1
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Aliphatic nitrogenous five-membered ring compounds
  申请人：——

  公开号：US20040063935A1

  公开（公告）日：2004-04-01

  The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: 1 wherein A represents —CH 2 — or —S—, R 1 represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower alkoxy lower alkyl group, X represents —N(R 3 )—, —O— or —CO—, where R 3 represents hydrogen atom or a lower alkyl group, and R 2 represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted, or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.

  本发明提供了一种脂肪族氮含有5元环化合物，其化学式表示为[I]：其中，A代表—CH2—或—S—，R1代表氢原子、低碳基、羟基低碳基或低烷氧基低碳基，X代表—N(R3)—、—O—或—CO—，其中R3代表氢原子或低碳基，而R2代表(1)可能被取代的环状基团，或(2)可能被取代的氨基基团，或其药学上可接受的盐，以及制备上述化合物的方法和包含上述化合物作为有效成分的制药组合物。
• Aliphatic nitrogen - containing 5 - membered ring compound
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：US20040229926A1

  公开（公告）日：2004-11-18

  The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: 1 wherein A represents —CH 2 — or —S—, R 1 represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower-alkoxy lower alkyl group, X represents —N(R 3 )—, —O— or —CO—, where R 3 represents hydrogen atom or a lower alkyl group, and R 2 represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted, or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.

  本发明提供一种脂肪族含氮的五元环化合物，其化学式为[I]:1，其中A代表—CH2—或—S—，R1代表氢原子、低碳基、羟基低碳基或低烷氧基低碳基，X代表—N(R3)—、—O—或—CO—，其中R3代表氢原子或低碳基，而R2代表(1)可能被取代的环状基团，或(2)可能被取代的氨基基团，或其药学上可接受的盐，以及制备上述化合物的方法和包含上述化合物作为有效成分的制药组合物。
• ALIPHATIC NITROGENOUS FIVE-MEMBERED RING COMPOUNDS
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1325910A1

  公开（公告）日：2003-07-09

  The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I] :    wherein A represents -CH2- or -S-,    R1 represents hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group or a lower alkoxy lower alkyl group,    X represents -N(R3)-, -O- or -CO-, where R3 represents hydrogen atom or a lower alkyl group, and    R2 represents (1) a cyclic group which may be substituted, or (2) an amino group which may be substituted, or a pharmaceutically acceptable salt thereof, a method for preparing the above-mentioned compound and a pharmaceutical composition comprising the above-mentioned compound as an effective ingredient.

  本发明旨在提供一种由式[I]代表的脂肪族含氮 5 元环化合物： 其中A代表-CH2-或-S-、 R1代表氢原子、低级烷基、羟基低级烷基或低级烷氧基低级烷基、 X代表-N(R3)-、-O-或-CO-，其中R3代表氢原子或低级烷基，R2代表(1)可被取代的环状基团，或(2)可被取代的氨基、 或其药学上可接受的盐、制备上述化合物的方法和包含上述化合物作为有效成分的药物组合物。
• US6849622B2
  申请人：——

  公开号：US6849622B2

  公开（公告）日：2005-02-01
• US7160877B2
  申请人：——

  公开号：US7160877B2

  公开（公告）日：2007-01-09