2-(furan-3-yl)phenol | 76815-77-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(furan-3-yl)phenol
• 英文别名: 2-(3-Furanyl)phenol
• CAS: 76815-77-5
• 化学式: C₁₀H₈O₂
• 分子量: 160.172
• InChiKey: LILAGBKMHJGVJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(furan-3-yl)phenol 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-Furan-3-yl-phenoxymethyl)-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines

  摘要：

  Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00764-8
• 作为产物：
  描述：

  3-(2-甲氧基苯基)呋喃 在 吡啶盐酸盐 作用下， 生成 2-(furan-3-yl)phenol
  参考文献：
  名称：

  α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines

  摘要：

  Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00764-8

文献信息

• Beta 3 adrenergic agonists
  申请人：Sall Jon Daniel

  公开号：US20050080110A1

  公开（公告）日：2005-04-14

  The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity.

  本发明涉及一种β3肾上腺素能受体激动剂，其化学式为（I）；或其药用盐；该激动剂能够增加细胞中的脂解和能量消耗，因此，它可以用于治疗2型糖尿病和/或肥胖等疾病。
• Beta3 adrenergic agonists
  申请人：——

  公开号：US20030191156A1

  公开（公告）日：2003-10-09

  The present invention relates to a &bgr; 3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.

  本发明涉及一种式(I)的&bgr;3肾上腺素受体激动剂或其药物盐，该激动剂能够增加细胞的脂解和能量消耗，因此可用于治疗II型糖尿病和/或肥胖症。该化合物还可用于降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠道蠕动。此外，该化合物还可用于减少神经源性炎症或作为抗抑郁剂。还公开了在治疗糖尿病和肥胖症以及降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠道蠕动方面使用该化合物的组合物和方法。
• Aryl-substituted furnaces
  申请人：Beiersdorf Aktiengesellschaft

  公开号：US04265903A1

  公开（公告）日：1981-05-05

  Aryl substituted furnaces and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, halogen, alkyl and acylamino having 1 to 4 carbon atoms, R.sub.3 and R.sub.4 may be the same or different and are selected from hydrogen and methyl, R.sub.5 is selected from hydrogen, dimethoxyphenyl and acylamino having the following formula R.sub.6 --CONH-- wherein R.sub.6 is selected from alkyl having 1 to 4 carbon atoms, are disclosed which are useful as anti-hypertensive and .beta.-adrenolytic agents. Also, substituted furnaces having the formula ##STR2## wherein R.sub.7 is selected from hydrogen, benzyl, the radical ##STR3## and the radical ##STR4## wherein X is selected from chlorine and bromine, are disclosed which are useful in the preparation of the aryl substituted furnaces. Compositions containing the aryl substituted furnaces, and methods of preparation are also disclosed.

  根据以下式子##STR1##，其中R.sub.1和R.sub.2可以相同或不同，选择自1至4个碳原子的氢，卤素，烷基和酰胺基，R.sub.3和R.sub.4可以相同或不同，选择自氢和甲基，R.sub.5选择自氢，二甲氧基苯基和具有以下式子R.sub.6 --CONH--的酰胺基，其中R.sub.6选择自1至4个碳原子的烷基，这些化合物是作为抗高血压和β-肾上腺素受体拮抗剂有用的芳基取代炉和药学上可接受的酸盐。此外，还披露了具有以下式子##STR2##，其中R.sub.7选择自氢，苄基，基团##STR3##和基团##STR4##，其中X选择自氯和溴，这些化合物在芳基取代炉的制备中是有用的。还披露了含有芳基取代炉的组合物和制备方法。
• BETA3 ADRENERGIC AGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1303509A1

  公开（公告）日：2003-04-23
• INDOLE DERIVATIVES AS BETA-3 ADRENERGIC AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1421078B1

  公开（公告）日：2006-09-27