Chlormethyl-dimethylaminochlorophosphin | 4141-71-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: Chlormethyl-dimethylaminochlorophosphin
• 英文别名: N,N-Dimethylchloromethylphosphonamidous chloride；Dimethylamino-(chlormethyl)-chlorphosphin；diethylaminochloromethylchlorophosphine；N-[chloro(chloromethyl)phosphanyl]-N-methylmethanamine
• CAS: 4141-71-3
• 化学式: C₃H₈Cl₂NP
• mdl: MFCD19232236
• 分子量: 159.983
• InChiKey: QPLLUUAEBFAXGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  四(三苯基膦)钯 、 Chlormethyl-dimethylaminochlorophosphin 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Selective C–Cl versus P–Cl activation—syntheses of complexes with P–Cl functional phosphinomethyl bridges η2,μ2-{P(R)Cl–CH2}

  摘要：

  On reaction of chloromethylchlorophosphines Cl(R)P-CH2-Cl with Pd(Ph3P)(4) the C-Cl bond is selectively activated by oxidative addition to Pd(0), unusual dipalladium complexes with P-Cl functional eta(2),mu(2){CH2-P(R)Cl} bridges being formed with high diastereoselectivity. The X-ray structure of 3a (R = tBu) reveals a chair-shaped Pd2P2C2 six-membered ring system with the substituents (Cl, tBu) at the two m(2)-P atoms in cis-position. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(97)00717-1
• 作为产物：
  描述：

  二氯(氯甲基)膦 、 二甲胺 以 乙醚 为溶剂， 生成 Chlormethyl-dimethylaminochlorophosphin
  参考文献：
  名称：

  1048.磷-氟化学。第十六部分。烷基-和芳基-二烷基氨基氟膦和膦的化学

  摘要：

  DOI：

  10.1039/jr9650005630

文献信息

• 1048. Phosphorus–fluorine chemistry. Part XVI. Chemistry of alkyl- and aryl-dialkylaminofluoro-phosphoranes and -phosphines
  作者：Reinhard Schmutzler

  DOI：10.1039/jr9650005630

  日期：——
• Selective C–Cl versus P–Cl activation—syntheses of complexes with P–Cl functional phosphinomethyl bridges η2,μ2-{P(R)Cl–CH2}
  作者：Peter Machnitzki、Othmar Stelzer、William S Sheldrick、Claudia Landgrafe

  DOI：10.1016/s0022-328x(97)00717-1

  日期：1998.3

  On reaction of chloromethylchlorophosphines Cl(R)P-CH2-Cl with Pd(Ph3P)(4) the C-Cl bond is selectively activated by oxidative addition to Pd(0), unusual dipalladium complexes with P-Cl functional eta(2),mu(2)CH2-P(R)Cl} bridges being formed with high diastereoselectivity. The X-ray structure of 3a (R = tBu) reveals a chair-shaped Pd2P2C2 six-membered ring system with the substituents (Cl, tBu) at the two m(2)-P atoms in cis-position. (C) 1998 Elsevier Science S.A. All rights reserved.