(+/-)-N-methylsalsolinol hydrobromide | 1232653-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (+/-)-N-methylsalsolinol hydrobromide
• 英文别名: 1,2-dimethyl-3,4-dihydro-1H-isoquinoline-6,7-diol;hydrobromide
• CAS: 1232653-14-3
• 化学式: BrH*C₁₁H₁₅NO₂
• 分子量: 274.158
• InChiKey: HREUKUWKRRDPRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  43.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  卡乃津盐酸盐 在 氢溴酸 作用下， 反应 2.0h， 以64.8%的产率得到(+/-)-N-methylsalsolinol hydrobromide
  参考文献：
  名称：

  Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities

  摘要：

  Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N- or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.

  DOI：

  10.3987/com-10-11912

文献信息

• Geranyl Derivatives of Isoquinoline Alkaloids Show Increased Biological Activities
  作者：Kinuko Iwasa、Yumi Nishiyama、Suguru Okada、Sousuke Takeuchi、Masataka Moriyasu、Miyoko Kamigauchi、Junko Koyama、Atsuko Takeuchi、Harukuni Tokuda、Hye-Sook Kim、Yusuke Wataya、Kazuyoshi Takeda、Yi-Nan Liu、Pei-Chi Wu、Kenneth F. Bastow、Toshiyuki Akiyama、Kuo-Hsiung Lee

  DOI：10.3987/com-10-11912

  日期：——

  Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N- or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.