alpha-甲基胆碱 | 21618-46-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: alpha-甲基胆碱
• 中文别名: 5-羟甲基糠醛
• 英文名称: 2-Propanaminium, 1-hydroxy-N,N,N-trimethyl-
• 英文别名: 1-hydroxypropan-2-yl(trimethyl)azanium
• CAS: 21618-46-2
• 化学式: C6H16NO+
• 分子量: 118.2
• InChiKey: CQAUBRYQGMZJLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2923900090

文献信息

• Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：novosom AG

  公开号：EP1911443A1

  公开（公告）日：2008-04-16

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由脂质混合物组成，所述混合物包括阳离子两性化合物、阴离子两性化合物和一种或多种中性两性化合物、所述阳离子和阴离子双亲化合物中至少有一种是可带电的，且阳离子和阴离子双亲化合物各自的量应选择为：在第一个较低的 pH 值下，带正电的阳离子双亲化合物按比例过量，在第二个较高的 pH 值下，带负电的阴离子双亲化合物按比例过量，且所述混合物的等电点介于所述第一和第二 pH 值之间；其特征在于，所述带正电荷的阳离子和带负电荷的阴离子两性化合物可在所述等电点相互形成脂盐。还公开了预测两性脂质体在给定 pH 值下的溶融性、配制两性脂质体和用货物分子装载两性脂质体的方法。
• Improvements in or relating to amphoteric liposomes.
  申请人：Marina Biotech, Inc.

  公开号：EP2462924A2

  公开（公告）日：2012-06-13

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  由脂质混合物组成的两性脂质体，所述混合物包括阳离子两性亲和物、阴离子两性亲和物和一种或多种中性两性亲和物。还公开了预测两性脂质体在给定 pH 值下的溶融性、配制两性脂质体和用货物分子装载两性脂质体的方法。
• Hydrophilic film for ex vivo membrane
  申请人：ETERNAL MATERIALS CO., LTD.

  公开号：US10024847B2

  公开（公告）日：2018-07-17

  The present invention provides a hydrophilic film for an ex vivo membrane, which includes: a substrate; and a hydrophilic coating located on at least one surface of the substrate and formed by a hydrophilic composition, in which the hydrophilic composition includes: (a) a reactive adhesive; (b) a surfactant having reactivity; and (c) optionally a polyol.

  本发明提供了一种用于体外膜的亲水薄膜，其中包括 基底；以及 亲水涂层，位于基底的至少一个表面上，由亲水组合物形成，其中亲水组合物包括 (a) 反应性粘合剂 (b) 具有反应性的表面活性剂；以及 (c) 可选的多元醇。
• Endovascular catheters and methods for carotid body ablation
  申请人：Gelfand Mark

  公开号：US10219855B2

  公开（公告）日：2019-03-05

  Systems, devices, and methods for treating a patient having a sympathetically mediated disease associated at least in part with augmented peripheral chemoreflex or heightened sympathetic activation. The treatments include ablating one or more peripheral chemoreceptors or associated afferent nerves to reduce or remove afferent neural signals from the peripheral chemoreceptor.

  用于治疗交感神经介导疾病患者的系统、设备和方法，该疾病至少部分与外周化学感受器增强或交感神经激活增强有关。治疗方法包括消融一个或多个外周化学感受器或相关传入神经，以减少或消除来自外周化学感受器的传入神经信号。
• Deep eutectic solvents and/or ionic liquids in cell culture media
  申请人：Merck Patent GmbH

  公开号：US10731126B2

  公开（公告）日：2020-08-04

  The present invention relates to cell culture media compositions comprising deep eutectic solvents and/or ionic liquids.

  本发明涉及由深共晶溶剂和/或离子液体组成的细胞培养基组合物。