3-(4-fluorophenyl)-4-hydroxy-2-(4-hydroxyphenyl)-2H-furan-5-one | 1042035-64-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-(4-fluorophenyl)-4-hydroxy-2-(4-hydroxyphenyl)-2H-furan-5-one
• CAS: 1042035-64-2
• 化学式: C₁₆H₁₁FO₄
• 分子量: 286.259
• InChiKey: YHLKSHTZCOBTHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-(4-fluorophenyl)-4-hydroxy-2-(4-phenylmethoxyphenyl)-2H-furan-5-one 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 5.0h， 以71%的产率得到3-(4-fluorophenyl)-4-hydroxy-2-(4-hydroxyphenyl)-2H-furan-5-one
  参考文献：
  名称：

  Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

  摘要：

  A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.08.005

文献信息

• Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones
  作者：Fabrice Bailly、Clémence Queffélec、Gladys Mbemba、Jean-François Mouscadet、Nicole Pommery、Jean Pommery、Jean-Pierre Hénichart、Philippe Cotelle

  DOI：10.1016/j.ejmech.2007.08.005

  日期：2008.6

  A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test. (c) 2007 Elsevier Masson SAS. All rights reserved.