beta-氨基-1H-咪唑-5-丙醇盐酸盐

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: beta-氨基-1H-咪唑-5-丙醇盐酸盐
• 英文名称: 2-amino-3-(1H-imidazol-5-yl)propan-1-ol;hydron;dichloride
• 化学式: C6H13Cl2N3O
• 分子量: 214.09
• InChiKey: FRCAFNBBXRWXQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  74.9
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• N-SUBSTITUTED PYRROLIDINES
  申请人：Chu Xin-Jie

  公开号：US20120010235A1

  公开（公告）日：2012-01-12

  Compounds of formula and enantiomers and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control, amelioration or prevention of cancer.

  描述了公式的化合物及其对映体和药用可接受的盐，以及含有该化合物及其药用可接受的盐的药物组合物，以及该化合物和药物组合物用于治疗、控制、改善或预防癌症的用途。
• Histidinol dehydrogenase protein, DNA and muteins and transgenic plants thereof
  申请人：CIBA-GEIGY AG

  公开号：EP0478502A2

  公开（公告）日：1992-04-01

  The present invention comprises cDNA coding for histidinol dehydrogenase from plants, the final step in histidine biosynthesis. The invention also comprises a novel method of purifying histidinol dehydrogenase from plants to essential honogeneity, the purified histidinol dehydrogenase, an assay for identifying inhibitors of histidinol dehydrogenase, an assay to identify mutants of histidinol dehydrogenase that are not inhibited by inhibitors of wild-type histidinol dehydrogenase, the inhibitors so identified as well as herbicide compositions containing them, the non-inhibited mutants of histidinol dehydrogenase, transgenic crop plants containing the non-inhibited mutants of histidinol dehydrogenase, and methods of treating weeds utilizing the application of histidinol dehydrogenase inhibitors to the transgenic crops containing the non-inhibited mutants of histidinol dehydrogenase.

  本发明包括植物组氨醇脱氢酶的 cDNA 编码，这是组氨酸生物合成的最后一步。本发明还包括一种从植物中纯化组氨醇脱氢酶至基本纯度的新方法、纯化的组氨醇脱氢酶、鉴定组氨醇脱氢酶抑制剂的检测方法、鉴定不受野生型组氨醇脱氢酶抑制剂抑制的组氨醇脱氢酶突变体的检测方法、组氨醇脱氢酶的非抑制突变体、含有组氨醇脱氢酶非抑制突变体的转基因作物植株，以及利用向含有组氨醇脱氢酶非抑制突变体的转基因作物施用组氨醇脱氢酶抑制剂来处理杂草的方法。
• Urea nucleosides as therapeutic and diagnostic agents
  申请人：GILEAD SCIENCES, INC.

  公开号：US20030069414A1

  公开（公告）日：2003-04-10

  Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidine ring, with a vinylstannane, carbon monoxide, and a palladium catalyst to provide 1-ene-3-one intermediates. These intermediates are then reacted with suitably functionalized primary or secondary amines via a Michael reaction. When the intermediate is a 5-position modified pyrimidine ring, and the amine contains a second hydrogen, it can do a second Michael reaction with the ene-one or the ene-imine in the pyrimidine ring. Appropriate modification of the amine reactant can yield products with various bioactivities. The nucleosides can be used therapeutically as anti-cancer, anti-bacterial or anti-viral drugs. The nucleosides can also be used for diagnostic applications, for example, by incorporating a radiolabel or fluorescent label into the molecule. The nucleosides can be used to prepare oligonucleotides for use in various applications, either alone or in combination with other modified nucleosides and/or naturally occurring nucleosides.

  本发明公开了修饰核苷以及制造和使用核苷的方法。这些化合物的制备方法是将在嘌呤或嘧啶环的一个或多个碳原子上含有合适离去基团的核苷起始原料与乙烯基锡烷、一氧化碳和钯催化剂反应，生成 1-烯-3-酮中间体。然后，这些中间体通过迈克尔反应与适当官能化的伯胺或仲胺发生反应。当中间体是一个 5 位修饰的嘧啶环，并且胺中含有第二个氢时，它可以与嘧啶环中的烯酮或烯亚胺发生第二次迈克尔反应。对胺反应物进行适当的修饰，可以得到具有各种生物活性的产物。核苷可用作抗癌、抗菌或抗病毒药物。核苷还可用于诊断，例如在分子中加入放射性标记或荧光标记。核苷可用于制备寡核苷酸，单独使用或与其他改性核苷和/或天然核苷结合使用，以用于各种应用。
• Reagent for the isolation of RNA
  申请人：Invitrogen Corporation

  公开号：US20030078412A1

  公开（公告）日：2003-04-24

  The present invention provides RNA extraction reagents, methods and kits that are especially useful for extracting RNA. The reagents, methods and kits of the present invention are especially useful for extracting RNA, for example, cytoplasmic RNA, from difficult materials, from plants, especially, difficult plant tissues, such as those containing phenolics, tannins, polysaccharides (such as starch) and resins. Comparative high yields are obtainable according to the present invention when compared to conventional reagents and methods. The RNA preparations obtained in accordance with the present invention are also of high quality as demonstrated by superior A 260/280 results and by gel electrophoresis.

  本发明提供了特别适用于提取 RNA 的 RNA 提取试剂、方法和试剂盒。本发明的试剂、方法和试剂盒特别适用于从植物等难提取材料中提取 RNA，例如细胞质 RNA，尤其是难提取的植物组织，如含有酚类、单宁酸、多糖（如淀粉）和树脂的组织。与传统试剂和方法相比，根据本发明可获得比较高的产量。根据本发明获得的 RNA 制剂也具有很高的质量，这体现在其卓越的 A 260/280 结果和凝胶电泳结果表明，本发明制备的 RNA 质量也很高。
• RNA isolation reagent and methods
  申请人：Invitrogen Corporation

  公开号：US20030204077A1

  公开（公告）日：2003-10-30

  The invention provides methods, extraction reagents and kits for RNA isolation from eukaryotic cells such as plant or animal cells, where a phenol, a phenol solubilizer, a chelator and a nonionic detergent are used in the extraction reagent to replace the need for chaotropes and/or RNase inhibitors.

  本发明提供了从真核细胞（如植物或动物细胞）中分离 RNA 的方法、提取试剂和试剂盒，其中在提取试剂中使用了苯酚、苯酚增溶剂、螯合剂和非离子去污剂，以取代对混沌素和/或 RNase 抑制剂的需求。

表征谱图