(3-Butoxy-3-methyl-2-oxo-butyl)-phosphonic acid dimethyl ester | 62466-52-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (3-Butoxy-3-methyl-2-oxo-butyl)-phosphonic acid dimethyl ester
• 英文别名: Dimethyl (3-butoxy-3-methyl-2-oxobutyl)phosphonate；3-butoxy-1-dimethoxyphosphoryl-3-methylbutan-2-one
• CAS: 62466-52-8
• 化学式: C₁₁H₂₃O₅P
• 分子量: 266.274
• InChiKey: OAYBDMLNONIPKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0365678A1

  公开（公告）日：1990-05-02

  2,5,6,7-Tetranor-4,8-inter-m-phenylene PGl2 derivatives such as 16-methyl-2,5,6,-tetranor-4,8-!nter-m-phenylene PGl2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGl2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-l-nter-m- phenylene PGl2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor--4,8-inter-m-phenylene PG12, 16-methyl-16-phenoxy-2.5,6,7,17,18,19,20-octanor-4, 8- ,inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8--inter-m- phenylene PGl2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5.6.7,18,19,20-heptanor- 4,8-inter-m-phenylene PG12, useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents.

  nter-m-phenylene PGl2 及其甲酯、17-甲基-2,5,6,7-tetranor-4,8-inter-m-phenylene PGl2 及其甲酯、15-苯基-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2、16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-l-nter-m- phenylene PGl2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor--4,8-inter-m-phenylene PG12, 16-methyl-16-phenoxy-2.5,6,7,17,18,19,20-辛硼烷-4,8-间亚苯基 PGI2、16-甲基-16-苯氧基-2,5,6,7,18,19,20-庚硼烷-4,8-间亚苯基 PGl2 及其甲酯和 3-癸羧基-3-羟甲基-16-甲基-16-苯氧基-2,5,6,7,18,19,20-庚硼烷-4,8-间亚苯基 PGl2 及其甲酯。6.7,18,19,20-heptanor- 4,8-inter-m-phenylene PG12，可用作药物。这些衍生物可用作抗溃疡剂、降血压剂和抗血栓剂等。
• US4307112A
  申请人：——

  公开号：US4307112A

  公开（公告）日：1981-12-22
• US5401768A
  申请人：——

  公开号：US5401768A

  公开（公告）日：1995-03-28