7,9-dimethyl-3,7,8,9-tetrahydro-purine-2,6-dione | 58526-75-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7,9-dimethyl-3,7,8,9-tetrahydro-purine-2,6-dione
• 英文别名: 7,9-Dimethyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione；7,9-dimethyl-3,8-dihydropurine-2,6-dione
• CAS: 58526-75-3
• 化学式: C₇H₁₀N₄O₂
• 分子量: 182.182
• InChiKey: OSCRZLORGNTZPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Highly branched alpha-D-glucans
  申请人：Purdue Research Foundation

  公开号：US10117937B2

  公开（公告）日：2018-11-06

  Compositions including a highly branched alpha-D-glucan or modified forms thereof and a solute compound are described herein. The compositions can provide increased water solubility and/or increased rate of dissolution for the solute compound. The compositions can also provide increased stability for the solute compound. Methods for preparing and using compositions including a solute compound and a highly branched alpha-D-glucan are also described.

  本文描述了包括高支链α-D-葡聚糖或其改良形式和溶质化合物的组合物。这些组合物可以提高溶质化合物的水溶性和/或溶解速率。这些组合物还能提高溶质化合物的稳定性。本文还描述了制备和使用包括溶质化合物和高支化α-D-葡聚糖的组合物的方法。
• Hydrophobic highly branched carbohydrate polymers
  申请人：Purdue Research Foundation

  公开号：US10653784B2

  公开（公告）日：2020-05-19

  A material comprising a highly branched carbohydrate polymer, a polyalkylene glycol (or polyalkylene oxide) linked to the highly branched carbohydrate polymer, and a hydrophobic or amphiphilic group linked to the highly branched carbohydrate polymer and/or the polyalkylene glycol (or polyalkylene oxide), is described. Methods of making and using the material, as well as a soluble composition that contains the material and a hydrophobic solute compound, are also described.

  本文描述了一种材料，该材料包含高支链碳水化合物聚合物、与高支链碳水化合物聚合物相连的聚亚烷基二醇（或聚亚烷基环氧乙烷）以及与高支链碳水化合物聚合物和/或聚亚烷基二醇（或聚亚烷基环氧乙烷）相连的疏水或两性基团。此外，还介绍了制造和使用该材料的方法，以及含有该材料和疏水性溶质化合物的可溶性组合物。
• HIGHLY BRANCHED ALPHA-D-GLUCANS
  申请人：Purdue Research Foundation

  公开号：EP2838564A1

  公开（公告）日：2015-02-25
• HYDROPHOBIC HIGHLY BRANCHED CARBOHYDRATE POLYMERS
  申请人：PHYTOPTION, LLC

  公开号：EP3356440A1

  公开（公告）日：2018-08-08
• Screening method
  申请人：——

  公开号：US20040013609A1

  公开（公告）日：2004-01-22

  The invention relates to a method for identification of substances which are applicable for treatment or prevention of an insufficient longitudinal growth of the eye (hypermetropia) or for treatment or prevention of an excessive longitudinal growth of the eye (myopia); substances identified by the method for treating or preventing conditions related to the longitudinal growth of the eye; substances and mixtures of substances for the preparation of a pharmaceutical composition for the treatment or prevention of abnormal growth of the axial length of the eye. The identification involves measuring the effect of the substances on the retinal pigment epithelium of the eye, e.g. by detecting the metabolic effect of the substance on the retinal epithelium, the effect on the standing potential or the effect on the proteoglycanes of the scleral tissue of the eye, by way of EOG examination, by way on the size of the so-called c-wave in ERG-recordings, or by the state of the Ca 2+ -channels or on the [ 3 H]-ryanodine receptors of the retinal pigment epithelium.