Benzamidchlorid | 57057-47-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Benzamidchlorid
• 英文别名: Dichloro(phenyl)methanamine
• CAS: 57057-47-3
• 化学式: C₇H₇Cl₂N
• 分子量: 176.045
• InChiKey: UQBKNQILGHFDMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  盐酸 、 苯甲腈 、 苯 生成 Benzamidchlorid
  参考文献：
  名称：

  Pinner; Klein, Chemische Berichte, 1877, vol. 10, p. 1890

  摘要：

  DOI：

文献信息

• Substituted quinolones II
  申请人：Schohe-Loop Rudolf

  公开号：US20080261964A1

  公开（公告）日：2008-10-23

  The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.

  这项发明涉及公式（I）的取代喹诺酮，以及它们的制备方法以及它们用于生产用于治疗和/或预防疾病的药物，特别是用作抗病毒剂，特别是针对巨细胞病毒的用途。
• Indole acetic acid acyl guanidines as beta-secretase inhibitors
  申请人：Thompson A. Lorin

  公开号：US20070049589A1

  公开（公告）日：2007-03-01

  There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  提供了一系列取代酰基胍啶化合物的化学式（I）或其立体异构体；或其药学上可接受的盐，其中R1、R2、R3、R4、R5、R6、R7和R8如本文所定义，它们的药物组合物和使用方法。这些化合物抑制β-分泌酶对淀粉样前体蛋白（APP）的加工，更具体地说，抑制Aβ肽的产生。本公开涉及对治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，如阿尔茨海默病和其他受抗淀粉样蛋白活性影响的情况。
• Calcium receptor active compounds
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US20030176485A1

  公开（公告）日：2003-09-18

  A novel calcium receptor active compound having the formula is provided: Ar 1 —[CR 1 R 2 ] p —X—[CR 3 R 4 ] q —[CR 5 R 6 ]—NR 7 —[CR 8 R 9 ]—Ar 2 wherein: Ar 1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl) amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are, for example, hydrogen or alkyl; Ar 2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.

  提供一种具有以下式子的新型钙受体活性化合物：Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2其中：Ar1选自芳基、杂芳基、双(芳基甲基)氨基、双(杂芳基甲基)氨基和芳基甲基(杂芳基甲基)氨基的群；X选自氧、硫、亚磺酰基、磺酰基、羰基和氨基的群；R1、R2、R3、R4、R5、R6、R7、R8和R9例如是氢或烷基；Ar2选自芳基和杂芳基的群；p为0至6的整数，包括0和6；q为0至14的整数，包括0和14。
• HIV integrase inhibitors
  申请人：——

  公开号：US20040110804A1

  公开（公告）日：2004-06-10

  The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds. 1

  本发明描述了一种新的化合物I的组合，该组合可以抑制HIV整合酶。本发明还描述了使用这些化合物进行艾滋病或ARC治疗的组合和方法。
• Calcium receptor-active compounds
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US20020107406A1

  公开（公告）日：2002-08-08

  A novel calcium receptor active compound having the formula is provided: Ar 1 —[CR 1 R 2 ] p —X—[CR 3 R 4 ] q —[CR 5 R 6 ]—NR 7 —[CR 8 R 9 ]—Ar 2 wherein: Ar 1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl) amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are, for example, hydrogen or alkyl; Ar 2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.

  提供了具有以下结构的一种新型钙受体活性化合物：Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2其中：Ar1选择自芳基、杂芳基、双(芳基甲基)氨基、双(杂芳基甲基)氨基和芳基甲基(杂芳基甲基)氨基的群；X选择自氧、硫、亚硫基、磺酰基、羰基和氨基的群；R1、R2、R3、R4、R5、R6、R7、R8和R9例如是氢或烷基；Ar2选择自芳基和杂芳基的群；p是从0到6的整数，包括0和6；q是从0到14的整数，包括0和14。