5,7-Dimethylquinoxaline | 1003707-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,7-Dimethylquinoxaline
• CAS: 1003707-24-1
• 化学式: C₁₀H₁₀N₂
• mdl: MFCD09955626
• 分子量: 158.203
• InChiKey: LRONGHRJOXENBN-UHFFFAOYSA-N

物化性质

• 沸点：
  275.9±35.0 °C(Predicted)
• 密度：
  1.109±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-Dimethylquinoxaline 在 二乙胺 作用下， 以 乙醇 为溶剂， 反应 15.08h， 生成 2,5,7,9-Tetramethyl-3,4-diacetyl-3a,4,9,9a-tetrahydro-cis-furo<2,3-b>-quinoxaline
  参考文献：
  名称：

  用双亲核试剂环化正烷基叠氮阳离子。4.β-二酮与喹喔啉鎓盐及其氮杂和苯并类似物反应的区域和立体特异性

  摘要：

  DOI：

  10.1007/bf00506466

文献信息

• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。
• Organic light emitting device
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US10038144B2

  公开（公告）日：2018-07-31

  An organic light-emitting device including a first electrode; a second electrode facing the first electrode; an emission layer between the first electrode and the second electrode; a hole transport region between the first electrode and the emission layer; and an electron transport region between the emission layer and the second electrode, wherein the hole transport region includes a first compound represented by Formula 1-1 or Formula 1-2, and wherein the electron transport region includes a second compound represented by Formula 2:

  一种有机发光器件，包括第一电极；面向第一电极的第二电极；位于第一电极和第二电极之间的发射层；位于第一电极和发射层之间的空穴传输区域；以及位于发射层和第二电极之间的电子传输区域，其中空穴传输区域包括由式 1-1 或式 1-2 表示的第一种化合物，而电子传输区域包括由式 2 表示的第二种化合物：
• Organic light-emitting device
  申请人：Samsung Display Co., Ltd

  公开号：US11329230B2

  公开（公告）日：2022-05-10

  Provided is an organic light-emitting device including a first compound and a second compound that offers low driving voltage and high efficiency. The organic light-emitting device includes an emission layer between a first electrode and a second electrode, and an electron transport region between the second electrode and the emission layer. The electron transport region includes the first compound. A hole transport region between the first electrode and the emission layer includes the second compound.

  本文提供了一种包括第一化合物和第二化合物的有机发光器件，该器件具有低驱动电压和高效率的特点。该有机发光器件包括位于第一电极和第二电极之间的发射层，以及位于第二电极和发射层之间的电子传输区域。电子传输区域包括第一化合物。第一电极和发射层之间的空穴传输区包括第二化合物。
• METHOD FOR AMPLIFYING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2218716B1

  公开（公告）日：2016-11-16