3-<2-Pyrrolidino-ethyl>-pyridin | 20173-28-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-<2-Pyrrolidino-ethyl>-pyridin
• 英文别名: N-(3-Pyridyl-ethyl)-pyrrolidin；3-(2-pyrrolidin-1-yl-ethyl)-pyridine；3-(2-Pyrrolidin-1-ylethyl)pyridine
• CAS: 20173-28-8
• 化学式: C₁₁H₁₆N₂
• 分子量: 176.261
• InChiKey: YWULZWMGJASRBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 2-(pyridin-3-yl)-ethyl methanesulfonate 以 乙腈 为溶剂， 生成 3-<2-Pyrrolidino-ethyl>-pyridin
  参考文献：
  名称：

  In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series

  摘要：

  Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.067

文献信息

• In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
  作者：Diana L. Nersesian、Lawrence A. Black、Thomas R. Miller、Timothy A. Vortherms、Timothy A. Esbenshade、Arthur A. Hancock、Marlon D. Cowart

  DOI：10.1016/j.bmcl.2007.10.067

  日期：2008.1

  Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.