2-Ethyl-3,5,7-trimethyl-3H-imidazo[4,5-b]pyridine | 156154-35-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-Ethyl-3,5,7-trimethyl-3H-imidazo[4,5-b]pyridine
• 英文别名: 2-ethyl-3,5,7-trimethylimidazo[4,5-b]pyridine
• CAS: 156154-35-7
• 化学式: C₁₁H₁₅N₃
• 分子量: 189.26
• InChiKey: SMCOIHUQXWNOIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TRICYCLIC COMPOUND
  申请人：Yanagisawa Arata

  公开号：US20110201640A1

  公开（公告）日：2011-08-18

  Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R 4 -R 9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R 10 and R 11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

  提供了一种三环化合物，具有PPARγ激动剂活性，其通式表示为（I），其中Z代表单键或类似物，Y代表氢原子，可选具有取代基的低碳基或类似物，X代表氢原子或类似物，A代表芳基或类似物，B和C相同或不同，每个代表芳香烃环或类似物，R4-R9相同或不同，每个代表氢原子或类似物，V代表单键或类似物，R10和R11相同或不同，每个代表氢原子或类似物，或其药学上可接受的盐或类似物。
• TRICYCLIC COMPOUNDS
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP1988091B1

  公开（公告）日：2015-06-10
• Combined agents for treatment of glaucoma
  申请人：Yokoyama Tomihisa

  公开号：US20080221184A1

  公开（公告）日：2008-09-11

  A pharmaceutical composition for the treatment of glaucoma which comprises an angiotensin II antagonist and a prostaglandin which is unoprostone or latanoprost, and a method for treatment of glaucoma by administering the composition to a patient.
• US7307096B2
  申请人：——

  公开号：US7307096B2

  公开（公告）日：2007-12-11
• US7872035B2
  申请人：——

  公开号：US7872035B2

  公开（公告）日：2011-01-18