cyclopropylboronate pinacol ester | 1310403-79-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硼酸衍生物
• 英文名称: cyclopropylboronate pinacol ester
• 英文别名: cyclopropylboronic acid pinacol ester；Cyclopropyl-(3-hydroxy-2,3-dimethylbutan-2-yl)oxyborinic acid
• CAS: 1310403-79-2
• 化学式: C₉H₁₉BO₃
• 分子量: 186.059
• InChiKey: MZCZFCWXIIOBOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cyclopropylboronate pinacol ester 在 盐酸 作用下， 生成 9-(4-cyclopropylphenyl)nonanoic acid
  参考文献：
  名称：

  NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE

  摘要：

  The present invention aims to provide a compound acting as a specific agonist for LPA4 receptors, and a pharmaceutical composition containing the compound. The present invention relates to a novel lysophosphatidic acid derivative having an agonistic action on LPA4 receptors and useful for the prophylaxis and/or treatment of diseases associated with angiogenesis abnormalities involving LPA4 receptors, diseases associated with vascular disorders, or the symptoms associated therewith, and a pharmaceutical composition containing the derivative.

  公开号：

  US20230146210A1

文献信息

• NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20230146210A1

  公开（公告）日：2023-05-11

  The present invention aims to provide a compound acting as a specific agonist for LPA4 receptors, and a pharmaceutical composition containing the compound. The present invention relates to a novel lysophosphatidic acid derivative having an agonistic action on LPA4 receptors and useful for the prophylaxis and/or treatment of diseases associated with angiogenesis abnormalities involving LPA4 receptors, diseases associated with vascular disorders, or the symptoms associated therewith, and a pharmaceutical composition containing the derivative.