9-Oxo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-fluorene-4-carboxamide | 1130067-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9-Oxo-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-9H-fluorene-4-carboxamide
• 英文别名: 9-oxo-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]fluorene-4-carboxamide
• CAS: 1130067-20-7
• 化学式: C₂₈H₂₆N₄O₃
• 分子量: 466.5
• InChiKey: INMSGESUKZJUQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS
  申请人：Vanderbilt University

  公开号：US20170319611A1

  公开（公告）日：2017-11-09

  Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase D inhibitors and/or Akt therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS<br/>[FR] THÉRAPIES ANTIVIRALES AVEC DES INHIBITEURS DE PHOSPHOLIPASE D
  申请人：UNIV VANDERBILT

  公开号：WO2013049773A1

  公开（公告）日：2013-04-04

  Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
• [EN] METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS<br/>[FR] PROCÉDÉS ET COMPOSITIONS COMPORTANT DES INHIBITEURS D'ATK ET/OU DES INHIBITEURS DE PHOSPHOLIPASE D
  申请人：UNIV VANDERBILT

  公开号：WO2014093557A1

  公开（公告）日：2014-06-19

  Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase D inhibitors and/or Akt therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• [EN] METHODS AND COMPOSITIONS OF TREATING HIV INFECTION<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT D'UNE INFECTION PAR LE VIH
  申请人：UNIV VANDERBILT

  公开号：WO2014093553A1

  公开（公告）日：2014-06-19

  Disclosed are methods of treating HIV infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.