丁二酰单胆碱 | 5518-77-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 丁二酰单胆碱
• 英文名称: TMAE succinate
• 英文别名: succinic acid mono-(2-trimethylammonio-ethyl ester)；Bernsteinsaeure-mono-(2-trimethylammonio-aethylester)；O-(3-Carboxy-propionyl)-cholin；Bernsteinsaeure-monocholinester；Succinoyl-cholin-kation；Succinyl-cholin-kation；Succinylmonocholine；2-(3-carboxypropanoyloxy)ethyl-trimethylazanium
• CAS: 5518-77-4
• 化学式: C₉H₁₈NO₄
• 分子量: 204.246
• InChiKey: JQLBLDAELQDYMK-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2923900090

反应信息

• 作为反应物：
  描述：

  丁二酰单胆碱 、 (2R)-2-amino-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)propan-1-ol 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以54%的产率得到(2R)-2-amino-2-N-(2-O-succinyl-choline)-3-((2,3-bis(octadecyloxy)propyl)disulfanyl)propan-1-ol chloride
  参考文献：
  名称：

  Synthesis of novel amphiphilic conjugates with a biological recognition function for developing targeted triggered liposomal delivery systems

  摘要：

  Several novel amphiphilic lipid derivatives were synthesized consisting of a lipid anchor connected to the hydrophilic moiety via a disulfide or glycoside bond and biotin linked to the hydrophilic part. Disulfide bonds were established by the help of 4-phenyltriazol-3,5-dione. Dansyl or fluorescein was covalently linked as fluorescent marker to some of the conjugates, allowing spectroscopic and microscopic detection. The conjugates represent first amphiphilic lipids carrying all four functions, i.e., lipophilic, hydrophilic, recognition, and disulfide cleavage group in one molecule, which are necessary for targeted, triggered drug delivery from phospholipid liposomes on demand. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.07.089

文献信息

• Process for the preparation of hydroxy polymer esters and their use
  申请人：Laine Aki

  公开号：US20070009464A1

  公开（公告）日：2007-01-11

  This invention covers a novel method for the preparation of hydroxy polymer esters of amino, alkylamino and quaternary ammonium acids and their use in several fields of industry, incuding the use as additives in the manufacture of paper or paperboard. The esterification of the hydroxy polymer, preferably starch, is performed under semianhydrous conditions by heating homogenized mixtures of the hydroxy polymer and reagents.

  这项发明涵盖了一种新颖的方法，用于制备氨基，烷基氨基和季铵酸的羟基聚合物酯，并在多个工业领域中使用，包括用作纸张或纸板制造中的添加剂。羟基聚合物（最好是淀粉）的酯化是在半无水条件下进行的，通过加热均质混合物来完成羟基聚合物和试剂的反应。
• Bioactive sensors
  申请人：Eichler Jutta

  公开号：US20050153357A1

  公开（公告）日：2005-07-14

  The present invention relates to sensors for the detection of molecular interactions between immobilized ligands and non-immobilized interaction partners (receptors). These surfaces use novel ligand-anchor conjugates which allow highly specific interaction with suitable interaction partners. Furthermore the invention relates to methods of providing the sensing surface and in particular methods of synthesising the ligand-anchor conjugates (LAC).

  本发明涉及用于检测固定配体和非固定相互作用伙伴（受体）之间分子相互作用的传感器。这些表面使用新型配体锚定物结合物，可以与适当的相互作用伙伴高度特异性地相互作用。此外，本发明涉及提供传感表面的方法，特别是合成配体锚定物结合物（LAC）的方法。
• COSMETIC INGREDIENT, COSMETIC, AND PRODUCTION METHOD FOR COSMETIC
  申请人：Miyoshi Oil & Fat Co., Ltd.

  公开号：EP3925671A1

  公开（公告）日：2021-12-22

  Provided are a novel cosmetic compounding agent capable of imparting superior properties such as a water and moisture retention property to a cosmetic for use on the hair and skin; a cosmetic using the cosmetic compounding agent; and a method for producing the cosmetic. The cosmetic compounding agent of the present invention contains an organic ammonium salt having a hydrogen-bonding functional group(s) in a cation and/or an anion. In a preferable embodiment, the cation is an ammonium cations represented by the following formula (I):         N+[R1]n[R2]4-n     (I) wherein each R1 independently represents, for example, a hydroxyalkyl group in which there is at least one hydroxy group, an alkyl moiety is a linear or branched moiety having 1 to 10 carbon atoms, and the alkyl moiety may contain an oxygen atom(s), and wherein each R2 independently represents a hydrogen atom or a linear or branched alkyl group having 1 to 18 carbon atoms, and n represents an integer of 0 to 4.

  本发明提供了一种新型化妆品复配剂，该复配剂能够赋予用于头发和皮肤的化妆品以优异的性能，例如保水保湿性能；一种使用该化妆品复配剂的化妆品；以及一种生产该化妆品的方法。本发明的化妆品复配剂含有一种有机铵盐，其阳离子和/或阴离子中具有氢键官能团。在一个较好的实施方案中，阳离子是由下式（I）代表的铵阳离子： N+[R1]n[R2]4-n (I) 其中每个 R1 独立地代表例如羟基烷基，其中至少有一个羟基，烷基是具有 1 至 10 个碳原子的直链或支链基团，烷基可含有一个或多个氧原子，以及 其中每个 R2 独立地代表氢原子或具有 1 至 18 个碳原子的直链或支链烷基，n 代表 0 至 4 的整数。
• COMPOSITION CONTAINING ORGANIC AMMONIUM SALT
  申请人：Miyoshi Oil & Fat Co., Ltd.

  公开号：EP3925672A1

  公开（公告）日：2021-12-22

  Provided is a novel composition with excellent stability which contains an organic ammonium salt. The composition containing an organic ammonium salt of the present invention contains an organic ammonium salt having a hydrogen-bonding functional group(s) in a cation and/or an anion, and a surfactant.

  本发明提供了一种稳定性极佳的新型组合物，其中含有一种有机铵盐。 本发明中含有有机铵盐的组合物包含一种在阳离子和/或阴离子中具有氢键官能团的有机铵盐和一种表面活性剂。
• SUXAMETHONIUM COMPOSITION AND PREFILLED SYRINGE THEREOF
  申请人：Laboratoire Aguettant

  公开号：EP3943068A1

  公开（公告）日：2022-01-26

  The present invention relates to a suxamethonium pharmaceutical composition comprising a succinic acid buffer. It also relates to a prefilled syringe thereof. The composition and the prefilled syringe of the invention are useful as ready-to-use formulations, especially in emergency conditions, and present long shelf lives, even at room temperature.

  本发明涉及一种包含琥珀酸缓冲液的舒喘宁药物组合物。本发明还涉及一种预灌封注射器。本发明的组合物和预灌封注射器可作为即用型制剂使用，特别是在紧急情况下，即使在室温下也有较长的保质期。