(10E)-14,15-dimethoxy-4-azabicyclo[11.3.1]heptadeca-1(17),10,13,15-tetraen-5-one | 1072928-30-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (10E)-14,15-dimethoxy-4-azabicyclo[11.3.1]heptadeca-1(17),10,13,15-tetraen-5-one
• CAS: 1072928-30-3
• 化学式: C₁₈H₂₅NO₃
• 分子量: 303.401
• InChiKey: ZUPGRUGSYGJJHE-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  hept-6-enoic acid [2-(3-allyl-4,5-dimethoxy-phenyl)ethyl]amide 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 19.5h， 生成 、 (10E)-14,15-dimethoxy-4-azabicyclo[11.3.1]heptadeca-1(17),10,13,15-tetraen-5-one
  参考文献：
  名称：

  A combined RCM-Bischler–Napieralski strategy towards the synthesis of the carbon skeleton of excentricine and related stephaoxocanes

  摘要：

  A convenient synthetic approach to a cyclodeca[ij]isoquinoline derivative, which embodies the carbon skeleton of excentricine and related stephaoxocanes, is described. The synthesis involves the combined use of ring closing metathesis and Bischler-Napieralski cyclizations for the construction of the homocyclic and nitrogen-bearing rings, respectively. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.005

文献信息

• A combined RCM-Bischler–Napieralski strategy towards the synthesis of the carbon skeleton of excentricine and related stephaoxocanes
  作者：Enrique L. Larghi、Teodoro S. Kaufman

  DOI：10.1016/j.tet.2008.08.005

  日期：2008.10

  A convenient synthetic approach to a cyclodeca[ij]isoquinoline derivative, which embodies the carbon skeleton of excentricine and related stephaoxocanes, is described. The synthesis involves the combined use of ring closing metathesis and Bischler-Napieralski cyclizations for the construction of the homocyclic and nitrogen-bearing rings, respectively. (C) 2008 Elsevier Ltd. All rights reserved.