Fmoc-(R)-3-amino-4-(3-pyridyl)-butyric acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-(R)-3-amino-4-(3-pyridyl)-butyric acid
• 英文别名: (3R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-pyridin-3-ylbutanoic acid
• 化学式: C₂₄H₂₂N₂O₄
• mdl: MFCD01860959
• 分子量: 402.4
• InChiKey: QBMDHZYUTBFELW-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.208
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Arymethylen substituted N-Acyl-gamma-aminoalcohols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1985612A1

  公开（公告）日：2008-10-29

  The present invention relates to arylmethylen substituted N-acyl-γ-aminoalcohols of the general formula I in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description. The compounds according to the invention are effective FSH modulators and can be used for example for fertility regulation in men or in women.

  本发明涉及一般式I中的芳基甲基取代的N-酰基-γ-氨基醇，其中Q、X、W、R1、R2、R3、R4和R5的含义如描述中所定义。本发明的化合物是有效的FSH调节剂，例如可用于男性或女性的生育调节。
• METHODS FOR DETECTION OF BOTULINUM NEUROTOXIN
  申请人：CITY OF HOPE

  公开号：US20140235490A1

  公开（公告）日：2014-08-21

  Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a low number of toxin molecules and to measure their intrinsic protease activity via conversion of a fluorogenic or luminescent substrate. Also provided herein are novel peptides that can be specifically cleaved by BoNT and novel peptides that are resistant to cleavage by BoNT. The combination of these cleavable and control peptides can be used for implementation of an exemplary ALISSA used to specifically detect BoNT enzymatic activity. Furthermore, the ALISSA as described herein may also be used in a column based format for use in a high-throughput system for testing large quantities of samples.
• US8067192B2
  申请人：——

  公开号：US8067192B2

  公开（公告）日：2011-11-29
• US9562903B2
  申请人：——

  公开号：US9562903B2

  公开（公告）日：2017-02-07