(20R,22R)-5α-cholestane-3β,6α,20,22-tetraol | 1151467-42-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (20R,22R)-5α-cholestane-3β,6α,20,22-tetraol
• 英文别名: (3S,5S,6S,8R,9S,10R,13S,14S,17S)-17-[(2R,3R)-2,3-dihydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol
• CAS: 1151467-42-3
• 化学式: C₂₇H₄₈O₄
• 分子量: 436.676
• InChiKey: WLTFEENGLHNKSP-ZYHYDSQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 水 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 6.5h， 以42%的产率得到(20R,22R)-5α-cholestane-3β,6α,20,22-tetraol
  参考文献：
  名称：

  Synthesis of ponasterone A derivatives with various steroid skeleton moieties and evaluation of their binding to the ecdysone receptor of Kc cells

  摘要：

  A series of ponasterone A (PNA) derivatives with various steroid moieties were synthesized to measure their binding activity to the ecdysone receptors of Drosophila Kc cells. The activity of compounds was evaluated by deter-mining the concentration required to give the 50% inhibition (IC50 in M) of the incorporation of [H-3]PNA to Drosophila Kc cells. Compounds with no functional groups such as OH and C=O group in the steroid skeleton moiety were inactive. By the introduction of functional groups such as the OH and the C=O group in the steroidal structure, these compounds became active. Some compounds containing the A/B-trans ring fusion, which is different from that (A/B-cis) of ecdysteroids were also active. The oxidation of CH2 at 6-position to C=O, enhanced the activity 19 times, but the activity was erased by the reduction of oxo to OH group at 6-position. The activity was enhanced about 250 times by the conversion of A/B ring configuration from trans [(20R,22R)-2 beta,3 beta,20,22-tetrahydroxy-5 alpha-cholestan-6-one: pIC(50) = 4.84] to cis [(20R,22R)-2 beta,3 beta,20,22-tetrahydroxy-5 beta-cholestan-6-one: pIC(50) = 7.23]. The latter cis-type compound which is the most potent among compounds synthesized in this study was equipotent to the natural molting hormone, 20-hydroxyecdysone, even though it is 1/50 of PNA. (C) 2008 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2008.08.005

文献信息

• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.
• Synthesis of ponasterone A derivatives with various steroid skeleton moieties and evaluation of their binding to the ecdysone receptor of Kc cells
  作者：Hirokazu Arai、Bunta Watanabe、Yoshiaki Nakagawa、Hisashi Miyagawa

  DOI：10.1016/j.steroids.2008.08.005

  日期：2008.12

  A series of ponasterone A (PNA) derivatives with various steroid moieties were synthesized to measure their binding activity to the ecdysone receptors of Drosophila Kc cells. The activity of compounds was evaluated by deter-mining the concentration required to give the 50% inhibition (IC50 in M) of the incorporation of [H-3]PNA to Drosophila Kc cells. Compounds with no functional groups such as OH and C=O group in the steroid skeleton moiety were inactive. By the introduction of functional groups such as the OH and the C=O group in the steroidal structure, these compounds became active. Some compounds containing the A/B-trans ring fusion, which is different from that (A/B-cis) of ecdysteroids were also active. The oxidation of CH2 at 6-position to C=O, enhanced the activity 19 times, but the activity was erased by the reduction of oxo to OH group at 6-position. The activity was enhanced about 250 times by the conversion of A/B ring configuration from trans [(20R,22R)-2 beta,3 beta,20,22-tetrahydroxy-5 alpha-cholestan-6-one: pIC(50) = 4.84] to cis [(20R,22R)-2 beta,3 beta,20,22-tetrahydroxy-5 beta-cholestan-6-one: pIC(50) = 7.23]. The latter cis-type compound which is the most potent among compounds synthesized in this study was equipotent to the natural molting hormone, 20-hydroxyecdysone, even though it is 1/50 of PNA. (C) 2008 Elsevier Inc. All rights reserved.