4-methyl-1-(5-phenyl-isoxazol-3-yl)-piperidine | 1130365-81-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-methyl-1-(5-phenyl-isoxazol-3-yl)-piperidine
• 英文别名: 3-(4-Methylpiperidin-1-yl)-5-phenyl-1,2-oxazole
• CAS: 1130365-81-9
• 化学式: C₁₅H₁₈N₂O
• 分子量: 242.321
• InChiKey: OXSYBZITNMISFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(5-phenyl-4,5-dihydro-isoxazol-3-yl)-4-methyl-piperidine 在 咪唑 、 碘 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以90%的产率得到4-methyl-1-(5-phenyl-isoxazol-3-yl)-piperidine
  参考文献：
  名称：

  Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines

  摘要：

  A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles Is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.

  DOI：

  10.1021/ol9000284

文献信息

• Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines
  作者：Mélina Girardin、Pamela G. Alsabeh、Sophie Lauzon、Sarah J. Dolman、Stéphane G. Ouellet、Greg Hughes

  DOI：10.1021/ol9000284

  日期：2009.3.5

  A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles Is described. In the presence of a base, readily available 3-bromoisoxazolines react with amines to afford 3-aminoisoxazolines. An oxidation protocol was developed for these heterocycles to provide 3-aminoisoxazoles in consistently high yield.