2-butoxy-8-(3,4-dichlorobenzyl)-4-morpholin-4-yl-5,8-dihydropteridine-6,7-dione | 1119576-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-butoxy-8-(3,4-dichlorobenzyl)-4-morpholin-4-yl-5,8-dihydropteridine-6,7-dione
• 英文别名: 2-butoxy-8-[(3,4-dichlorophenyl)methyl]-4-morpholin-4-yl-5H-pteridine-6,7-dione
• CAS: 1119576-56-5
• 化学式: C₂₁H₂₃Cl₂N₅O₄
• 分子量: 480.351
• InChiKey: NZLRVFNWXZXDFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  96.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-butoxy-N-(3,4-dichlorobenzyl)-6-morpholin-4-yl-5-nitrosopyrimidin-4,5-diamine 、 草酰氯单乙酯 以 N-甲基吡咯烷酮 为溶剂， 生成 2-butoxy-8-(3,4-dichlorobenzyl)-4-morpholin-4-yl-5,8-dihydropteridine-6,7-dione
  参考文献：
  名称：

  [EN] 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE
  [FR] COMPOSÉS CHIMIQUES - 795

  摘要：

  公开号：

  WO2009022185A3

文献信息

• [EN] CHEMICAL COMPOUNDS - 795<br/>[FR] COMPOSÉS CHIMIQUES - 795
  申请人：ASTRAZENECA AB

  公开号：WO2009022185A2

  公开（公告）日：2009-02-19

  The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial Murl inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faecalis or S.aureus infection. Further, the invention relates to methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of the compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments of use in the treatment and prevention of various bacterial diseases in a warm-blooded animal such as man.
• [EN] 6, 6-FUSED HETEROCYCLES, THEIR PHARMACEUTICAL COMPOSITIONS AND METHOS OF USE<br/>[FR] COMPOSÉS CHIMIQUES - 795
  申请人：ASTRAZENECA AB

  公开号：WO2009022185A3

  公开（公告）日：2009-07-09