三(1-甲基乙基)萘磺酸钠 | 1323-19-9

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 三(1-甲基乙基)萘磺酸钠
• 英文名称: Sodium triisopropylnaphthalenesulfonate
• 英文别名: sodium;3,6,7-tri(propan-2-yl)naphthalene-2-sulfonate
• CAS: 1323-19-9
• 化学式: C₃₄H₄₃N₂O₆Pol
• 分子量: 356.5
• InChiKey: GIRDAVLBQHUXJV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.12
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  C
• 安全说明：
  S26,S27,S36,S45
• 危险类别码：
  R34
• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  在 哌啶 、 N-甲基吡咯烷酮 作用下， 反应 0.33h， 生成 三(1-甲基乙基)萘磺酸钠
  参考文献：
  名称：

  Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity

  摘要：

  The unique reactivity of two sortase enzymes, SrtA(staph) from Staphylococcus aureus and SrtA(strep) from Streptococcus pyogenes, is exploited for site-specific labeling of a single polypeptide with different labels at its N and C termini. SrtA(strep) is used to label the protein's C terminus at an LPXTG site with a fluorescently labeled dialanine nucleophile. Selective N-terminal. labeling of proteins containing N-terminal glycine residues is achieved using SrtA(staph) and LPXT derivatives. The generality of N-terminal labeling with SrtA(staph) is demonstrated by near-quantitative labeling of multiple protein substrates with excellent site specificity.

  DOI：

  10.1021/ja902681k

文献信息

• Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity
  作者：John M. Antos、Guo-Liang Chew、Carla P. Guimaraes、Nicholas C. Yoder、Gijsbert M. Grotenbreg、Maximilian Wei-Lin Popp、Hidde L. Ploegh

  DOI：10.1021/ja902681k

  日期：2009.8.12

  The unique reactivity of two sortase enzymes, SrtA(staph) from Staphylococcus aureus and SrtA(strep) from Streptococcus pyogenes, is exploited for site-specific labeling of a single polypeptide with different labels at its N and C termini. SrtA(strep) is used to label the protein's C terminus at an LPXTG site with a fluorescently labeled dialanine nucleophile. Selective N-terminal. labeling of proteins containing N-terminal glycine residues is achieved using SrtA(staph) and LPXT derivatives. The generality of N-terminal labeling with SrtA(staph) is demonstrated by near-quantitative labeling of multiple protein substrates with excellent site specificity.

表征谱图