N-(2-methoxy-3-dibenzofuranyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-(2-methoxy-3-dibenzofuranyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide
• 英文别名: N-(2-methoxydibenzofuran-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide
• 化学式: C₂₆H₂₇N₃O₄
• 分子量: 445.518
• InChiKey: AAWAKHNQZZHFOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-氨基-2-甲氧基二苯并呋喃 在 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 6.0h， 生成 N-(2-methoxy-3-dibenzofuranyl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives

  摘要：

  In the present paper, a novel series of dibenzofuran-piperazine derivatives were synthesized via the treatment of N-(2-methoxy-3-dibenzofuranyl)-2-chloroacetamide with substituted piperazine derivatives. The chemical structures of the compounds were elucidated by H-1 NMR, C-13 NMR, mass spectral data; elemental analysis and HPLC analysis. Each derivative was evaluated for antiplatelet activity and anticholinesterase activity. Compound 2m with 2-furoyl moiety exhibited high percentage inhibition as much as standard drug aspirin on arachidonic acid (AA)-induced platelet aggregation. None of the compounds presented significant inhibitor effect on collagen-induced platelet aggregation. Furthermore, the anticholinesterase activity of the compounds was determined and they did not show promising inhibitor activity compared with standard drug donepezil.

  DOI：

  10.3109/14756366.2015.1108971

文献信息

• Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives
  作者：Leyla Yurttaş、Usama Abu Mohsen、Yeşim Ozkan、Simla Cobanoglu、Serkan Levent、Zafer Asım Kaplancikli

  DOI：10.3109/14756366.2015.1108971

  日期：2016.11.1

  In the present paper, a novel series of dibenzofuran-piperazine derivatives were synthesized via the treatment of N-(2-methoxy-3-dibenzofuranyl)-2-chloroacetamide with substituted piperazine derivatives. The chemical structures of the compounds were elucidated by H-1 NMR, C-13 NMR, mass spectral data; elemental analysis and HPLC analysis. Each derivative was evaluated for antiplatelet activity and anticholinesterase activity. Compound 2m with 2-furoyl moiety exhibited high percentage inhibition as much as standard drug aspirin on arachidonic acid (AA)-induced platelet aggregation. None of the compounds presented significant inhibitor effect on collagen-induced platelet aggregation. Furthermore, the anticholinesterase activity of the compounds was determined and they did not show promising inhibitor activity compared with standard drug donepezil.