2-(2,6-diisopropylphenyl)-5-methylisoindoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2,6-diisopropylphenyl)-5-methylisoindoline-1,3-dione
• 英文别名: 2-[2,6-di(propan-2-yl)phenyl]-5-methylisoindole-1,3-dione
• 化学式: C₂₁H₂₃NO₂
• 分子量: 321.419
• InChiKey: AAYGXRCKUAROMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基苯酐 、 2,6-二异丙基苯胺 反应 0.14h， 以97%的产率得到2-(2,6-diisopropylphenyl)-5-methylisoindoline-1,3-dione
  参考文献：
  名称：

  2-Aryl-1H-Isoindole-1,3-Dione 库的微波辅助平行合成

  摘要：

  描述了具有代表性的 28 成员邻苯二甲酰亚胺库的有效并行合成。平行层析以合适的纯度和高产率提供文库成员。

  DOI：

  10.1055/s-2002-19765

文献信息

• An efficient synthesis of N-substituted phthalimides using SiO2-tpy-Nb as heterogeneous and reusable catalyst
  作者：Li Wan、Xiaoning Sun、Songjie Shi、Jiawei Zhang、Xin Li、Zhenjiang Li、Kai Guo

  DOI：10.1016/j.catcom.2016.09.005

  日期：2017.1

  A novel and efficient heterogeneous catalyst SiO2-tpy-Nb was developed, and its application in the preparation of N-substituted phthalimides from o-phthalic acids or anhydrides with amines provides the desired products in good to excellent yields. The catalyst was stable and recoverable for eight consecutive cycles without a significant loss in its activity. Furthermore, the catalyst is applicable

  开发了一种新颖且有效的多相催化剂SiO 2 -tpy-Nb，其在由邻苯二甲酸或具有胺的酸酐制备N-取代的邻苯二甲酰亚胺中的应用以良好或优异的产率提供了所需的产物。该催化剂稳定且可连续八个循环回收，而活性没有明显损失。此外，该催化剂可连续使用，这表明其在工业化中的潜在利用。
• Inhibitors of NF-κB derived from thalidomide
  作者：Esperanza J. Carcache de-Blanco、Bulbul Pandit、Zhigen Hu、Jiandong Shi、Andrew Lewis、Pui-Kai Li

  DOI：10.1016/j.bmcl.2007.01.088

  日期：2007.11

  A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-kappaB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-kappaB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
• PHENYLPHTHALIMIDE ANALOGS FOR TREATING DIABETIC MACULAR EDEMA
  申请人：Ionescu Dumitru

  公开号：US20100247659A1

  公开（公告）日：2010-09-30

  Novel methods are provided to prevent blindness associated with diabetic macular edema by administration of a phenylphthalimide analog. Additionally, sustainability of the effect of administration of the phenylphthalimide analog is improved via encapsulation with poly(lactic-co-glycolic acid) nanoparticles. Finally, a novel method for synthesizing (2,6-diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione is disclosed.